Combining Dabigatran Etexilate Mesylate and Piroxicam is a major interaction and should generally be avoided without close medical supervision.
Combining piroxicam with dabigatran significantly increases your risk of serious bleeding, including stomach bleeding. Your doctor will likely recommend avoiding this combination.
Mechanism: Piroxicam, an NSAID, inhibits prostaglandin synthesis, which impairs platelet aggregation and damages the gastrointestinal mucosa. Dabigatran directly inhibits thrombin, preventing clot formation. The combination leads to additive antiplatelet and anticoagulant effects, alongside increased GI mucosal vulnerability.
Dabigatran Etexilate Mesylate vs. Piroxicam
Compare Dabigatran Etexilate Mesylate and Piroxicam: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Dabigatran Etexilate Mesylate
Pradaxa
Anticoagulants
RxDrug B
Piroxicam
Piroxicam
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Dabigatran Etexilate Mesylate | Piroxicam |
|---|---|---|
| Drug Class | Anticoagulants | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $400–$600/month | $10–$30/month |
Dabigatran Etexilate Mesylate Overview
Dabigatran (Pradaxa) is a medication that helps prevent blood clots from forming in your body. It works by directly blocking a substance called thrombin, which is essential for blood clotting. This medicine is primarily used to reduce the risk of stroke in people with a type of irregular heartbeat called atrial fibrillation, and to treat or prevent deep vein clots (DVT) and lung clots (PE) in cert...
Full Dabigatran Etexilate Mesylate guide →Piroxicam Overview
PIROXICAM (brand name: Piroxicam) is a NSAIDs. 1 INDICATIONS AND USAGE Piroxicam capsules are indicated: • For relief of the signs and symptoms of osteoarthritis. • For relief of the signs and symptoms of rheumatoid arthritis. Piroxicam capsules are a nonsteroidal anti-inflammatory drug indicated for •Relief of the signs and symptoms of…
Full Piroxicam guide →How Each Drug Works
Dabigatran Etexilate Mesylate
Dabigatran and its acyl glucuronides are competitive, direct thrombin inhibitors. Because thrombin (serine protease) enables the conversion of fibrinogen into fibrin during the coagulation cascade, its inhibition prevents the development of a thrombus. Both free and clot-bound thrombin, and thrombin-induced platelet aggregation are inhibited by the active moieties.
Piroxicam
Piroxicam has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of piroxicam capsules, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Piroxicam is a potent inhibitor of prostaglandin (PG) synthesis in vitro. Piroxicam concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in in…
Approved Uses (Indications)
Dabigatran Etexilate Mesylate
Capsules is a direct thrombin inhibitor indicated: To reduce the risk of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation For the treatment of deep venous thrombosis (DVT) and pulmonary embolism (PE) in adult patients who have been treated with a parenteral anticoagulant for 5-10 days To reduce the risk of recurrence of DVT and PE in adult patients who have been previously treated For the prophylaxis of DVT and PE in adult patients who have undergone hip replacement surgery For the treatment of …
Piroxicam
Piroxicam capsules are indicated:
- For relief of the signs and symptoms of osteoarthritis.
- For relief of the signs and symptoms of rheumatoid arthritis. Piroxicam capsules are a nonsteroidal anti-inflammatory drug indicated for
- Relief of the signs and symptoms of osteoarthritis (OA)
- Relief of the signs and symptoms of rheumatoid arthritis (RA)
Side Effects
Dabigatran Etexilate Mesylate
Piroxicam
Cost Comparison
Dabigatran Etexilate Mesylate
$400–$600/month
As Pradaxa is a brand-name medication without a generic, manufacturer coupons or patient assistance programs are often the best ways to reduce out-of-pocket costs.
Piroxicam
$10–$30/month
Piroxicam is available as an affordable generic. Patients can often find significant savings by using discount cards or coupons from services like GoodRx.
Compare prices for Dabigatran Etexilate Mesylate and Piroxicam
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.