Combining Diclofenac Sodium and Dipyridamole is a major interaction and should generally be avoided without close medical supervision.
Combining diclofenac (an NSAID) with dipyridamole (an antiplatelet) significantly increases your risk of bleeding, especially in the stomach or intestines. This combination should generally be avoided.
Mechanism: Diclofenac inhibits cyclooxygenase (COX-1 and COX-2), reducing prostaglandin synthesis, which can impair gastric mucosal protection and inhibit platelet aggregation. Dipyridamole inhibits phosphodiesterase, leading to increased cyclic AMP and reduced platelet aggregation. The combination results in additive antiplatelet effects and increased gastrointestinal toxicity.
Diclofenac Sodium vs. Dipyridamole
Compare Diclofenac Sodium and Dipyridamole: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Diclofenac Sodium
Diclofenac Sodium
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Dipyridamole
Dipyridamole
Antiplatelet Agents
RxQuick Comparison
| Category | Diclofenac Sodium | Dipyridamole |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | Antiplatelet Agents |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $10-$30/month | $150–$400/month |
Diclofenac Sodium Overview
DICLOFENAC SODIUM (brand name: Diclofenac Sodium) is a NSAIDs. 1 INDICATIONS AND USAGE Diclofenac sodium topical solution, USP is indicated for the treatment of signs and symptoms of osteoarthritis of the knee(s) (1). Diclofenac sodium topical solution is a nonsteroidal anti-inflammatory drug indicated for the treatment of signs and symptoms of osteoarthritis…
Full Diclofenac Sodium guide →Dipyridamole Overview
Dipyridamole is a medication that helps prevent blood clots. It works by making platelets, tiny blood cells involved in clotting, less sticky. This medicine is primarily used alongside other blood thinners to prevent dangerous blood clots after heart valve replacement surgery.
Full Dipyridamole guide →How Each Drug Works
Diclofenac Sodium
Diclofenac has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of diclofenac sodium, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Diclofenac is a potent inhibitor of prostaglandin synthesis in vitro. Diclofenac concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in induc…
Dipyridamole
Mechanism of Action Dipyridamole inhibits the uptake of adenosine into platelets, endothelial cells and erythrocytes in vitro and in vivo ; the inhibition occurs in a dose-dependent manner at therapeutic concentrations (0.5 mcg/mL to 1.9 mcg/mL). This inhibition results in an increase in local concentrations of adenosine which acts on the platelet A 2 -receptor thereby stimulating platelet adenylate cyclase and increasing platelet cyclic-3',5'-adenosine monophosphate (cAMP) levels. Via this mech…
Approved Uses (Indications)
Diclofenac Sodium
Diclofenac sodium topical solution, USP is indicated for the treatment of signs and symptoms of osteoarthritis of the knee(s) . Diclofenac sodium topical solution is a nonsteroidal anti-inflammatory drug indicated for the treatment of signs and symptoms of osteoarthritis of the knee(s).
Dipyridamole
INDICATIONS AND USAGE Dipyridamole tablets are indicated as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement.
Side Effects
Diclofenac Sodium
Dipyridamole
Cost Comparison
Diclofenac Sodium
$10-$30/month
Diclofenac sodium is widely available as a low-cost generic. Patients can often find significant savings by using discount cards or pharmacy loyalty programs.
Dipyridamole
$150–$400/month
Since Dipyridamole is only available as a brand-name drug, look for manufacturer coupons or patient assistance programs to help reduce the cost. Discount cards like GoodRx may also offer savings.
Compare prices for Diclofenac Sodium and Dipyridamole
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.