Combining Diclofenac Sodium and Prasugrel is a major interaction and should generally be avoided without close medical supervision.
Combining diclofenac with prasugrel significantly increases your risk of bleeding, especially in the stomach or intestines. This combination should generally be avoided.
Mechanism: Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase enzymes, reducing prostaglandin synthesis and impairing platelet aggregation. Prasugrel is an antiplatelet agent that irreversibly inhibits the P2Y12 ADP receptor on platelets, preventing platelet activation and aggregation. The concurrent use of these agents results in additive antiplatelet effects and increased gastrointestinal mucosal damage, leading to a substantially elevated bleeding risk.
Diclofenac Sodium vs. Prasugrel
Compare Diclofenac Sodium and Prasugrel: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Diclofenac Sodium
Diclofenac Sodium
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Prasugrel
Prasugrel
Antiplatelet Agents
RxQuick Comparison
| Category | Diclofenac Sodium | Prasugrel |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | Antiplatelet Agents |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $10-$30/month | $200–$500/month |
Diclofenac Sodium Overview
DICLOFENAC SODIUM (brand name: Diclofenac Sodium) is a NSAIDs. 1 INDICATIONS AND USAGE Diclofenac sodium topical solution, USP is indicated for the treatment of signs and symptoms of osteoarthritis of the knee(s) (1). Diclofenac sodium topical solution is a nonsteroidal anti-inflammatory drug indicated for the treatment of signs and symptoms of osteoarthritis…
Full Diclofenac Sodium guide →Prasugrel Overview
Prasugrel is an antiplatelet medication that helps prevent blood clots. It works by making your platelets less sticky, reducing the risk of serious heart problems like heart attack or stroke, especially after a procedure to open blocked heart arteries (PCI) for conditions like acute coronary syndrome.
Full Prasugrel guide →How Each Drug Works
Diclofenac Sodium
Diclofenac has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of diclofenac sodium, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Diclofenac is a potent inhibitor of prostaglandin synthesis in vitro. Diclofenac concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in induc…
Prasugrel
Prasugrel is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y 12 class of ADP receptors on platelets.
Approved Uses (Indications)
Diclofenac Sodium
Diclofenac sodium topical solution, USP is indicated for the treatment of signs and symptoms of osteoarthritis of the knee(s) . Diclofenac sodium topical solution is a nonsteroidal anti-inflammatory drug indicated for the treatment of signs and symptoms of osteoarthritis of the knee(s).
Prasugrel
Prasugrel tablets is a P2Y 12 platelet inhibitor indicated for the reduction of thrombotic cardiovascular events (including stent thrombosis) in patients with acute coronary syndrome who are to be managed with percutaneous coronary intervention (PCI) as follows: Patients with unstable angina or non-ST-elevation myocardial infarction (NSTEMI) . Patients with ST-elevation myocardial infarction (STEMI) when managed with either primary or delayed PCI . 1.1 Acute Coronary Syndrome Prasugrel tablet is indicated to reduce the rate of thrombotic cardiovascular (CV…
Side Effects
Diclofenac Sodium
Prasugrel
Cost Comparison
Diclofenac Sodium
$10-$30/month
Diclofenac sodium is widely available as a low-cost generic. Patients can often find significant savings by using discount cards or pharmacy loyalty programs.
Prasugrel
$200–$500/month
As PRASUGREL is a brand-only medication, patients should look for manufacturer coupons or patient assistance programs to help reduce the cost. Discount cards may also offer some savings.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.