Combining Diclofenac Sodium and Rivaroxaban is a major interaction and should generally be avoided without close medical supervision.
Combining diclofenac with rivaroxaban significantly increases your risk of bleeding, especially from the stomach or intestines. This combination should generally be avoided due to the serious bleeding potential.
Mechanism: Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), inhibits prostaglandin synthesis, which can impair gastric mucosal protection and inhibit platelet aggregation. Rivaroxaban is a direct oral anticoagulant that inhibits Factor Xa, preventing thrombin generation and clot formation. The concurrent use of these agents results in additive antiplatelet and anticoagulant effects, leading to a heightened risk of hemorrhage.
Diclofenac Sodium vs. Rivaroxaban
Compare Diclofenac Sodium and Rivaroxaban: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Diclofenac Sodium
Diclofenac Sodium
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Rivaroxaban
rivaroxaban
Anticoagulants
RxQuick Comparison
| Category | Diclofenac Sodium | Rivaroxaban |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | Anticoagulants |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $10-$30/month | $400–$600/month |
Diclofenac Sodium Overview
DICLOFENAC SODIUM (brand name: Diclofenac Sodium) is a NSAIDs. 1 INDICATIONS AND USAGE Diclofenac sodium topical solution, USP is indicated for the treatment of signs and symptoms of osteoarthritis of the knee(s) (1). Diclofenac sodium topical solution is a nonsteroidal anti-inflammatory drug indicated for the treatment of signs and symptoms of osteoarthritis…
Full Diclofenac Sodium guide →Rivaroxaban Overview
RIVAROXABAN (brand name: rivaroxaban) is a Anticoagulants. 1 INDICATIONS & USAGE Rivaroxaban is a factor Xa inhibitor indicated: to reduce the risk of major cardiovascular events in patients with coronary artery disease (CAD) ( 1.7 ) to reduce the risk of major thrombotic vascular events in patients with peripheral artery disease (PAD), including patients…
Full Rivaroxaban guide →How Each Drug Works
Diclofenac Sodium
Diclofenac has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of diclofenac sodium, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Diclofenac is a potent inhibitor of prostaglandin synthesis in vitro. Diclofenac concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in induc…
Rivaroxaban
Rivaroxaban is a selective inhibitor of FXa. It does not require a cofactor (such as Anti-thrombin III) for activity. Rivaroxaban inhibits free FXa and prothrombinase activity. Rivaroxaban has no direct effect on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin. By inhibiting FXa, rivaroxaban decreases thrombin generation.
Approved Uses (Indications)
Diclofenac Sodium
Diclofenac sodium topical solution, USP is indicated for the treatment of signs and symptoms of osteoarthritis of the knee(s) . Diclofenac sodium topical solution is a nonsteroidal anti-inflammatory drug indicated for the treatment of signs and symptoms of osteoarthritis of the knee(s).
Rivaroxaban
Rivaroxaban is a factor Xa inhibitor indicated: to reduce the risk of major cardiovascular events in patients with coronary artery disease (CAD) to reduce the risk of major thrombotic vascular events in patients with peripheral artery disease (PAD), including patients after recent lower extremity revascularization due to symptomatic PAD 1.7 Reduction of Risk of Major Cardiovascular Events in Patients with Coronary Artery Disease (CAD) Rivaroxaban tablets, in combination with aspirin, are indicated to reduce the risk of major cardiovascular events (cardiova…
Side Effects
Diclofenac Sodium
Rivaroxaban
Cost Comparison
Diclofenac Sodium
$10-$30/month
Diclofenac sodium is widely available as a low-cost generic. Patients can often find significant savings by using discount cards or pharmacy loyalty programs.
Rivaroxaban
$400–$600/month
As a brand-only medication, Rivaroxaban can be expensive. Check the manufacturer's website for patient assistance programs or coupons, and compare prices at different pharmacies using discount cards.
Compare prices for Diclofenac Sodium and Rivaroxaban
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.