Combining Dipyridamole and Indomethacin is a major interaction and should generally be avoided without close medical supervision.
Combining indomethacin with dipyridamole significantly increases your risk of bleeding, especially in the stomach or intestines. This combination should generally be avoided.
Mechanism: Indomethacin, an NSAID, inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis and impairing platelet aggregation. Dipyridamole is an antiplatelet agent that inhibits phosphodiesterase, leading to increased cyclic AMP and reduced platelet aggregation. The concurrent use of these agents results in additive antiplatelet effects, significantly prolonging bleeding time.
Dipyridamole vs. Indomethacin
Compare Dipyridamole and Indomethacin: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Dipyridamole
Dipyridamole
Antiplatelet Agents
RxDrug B
Indomethacin
Indomethacin
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Dipyridamole | Indomethacin |
|---|---|---|
| Drug Class | Antiplatelet Agents | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $150–$400/month | $30–$80/month |
Dipyridamole Overview
Dipyridamole is a medication that helps prevent blood clots. It works by making platelets, tiny blood cells involved in clotting, less sticky. This medicine is primarily used alongside other blood thinners to prevent dangerous blood clots after heart valve replacement surgery.
Full Dipyridamole guide →Indomethacin Overview
INDOMETHACIN (brand name: Indomethacin) is a NSAIDs. INDICATIONS AND USAGE Carefully consider the potential benefits and risks of indomethacin capsules and other treatment options before deciding to use indomethacin. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS ).…
Full Indomethacin guide →How Each Drug Works
Dipyridamole
Mechanism of Action Dipyridamole inhibits the uptake of adenosine into platelets, endothelial cells and erythrocytes in vitro and in vivo ; the inhibition occurs in a dose-dependent manner at therapeutic concentrations (0.5 mcg/mL to 1.9 mcg/mL). This inhibition results in an increase in local concentrations of adenosine which acts on the platelet A 2 -receptor thereby stimulating platelet adenylate cyclase and increasing platelet cyclic-3',5'-adenosine monophosphate (cAMP) levels. Via this mech…
Approved Uses (Indications)
Dipyridamole
INDICATIONS AND USAGE Dipyridamole tablets are indicated as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement.
Indomethacin
INDICATIONS AND USAGE Carefully consider the potential benefits and risks of indomethacin capsules and other treatment options before deciding to use indomethacin. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS ). Indomethacin Capsule, USP has been found effective in active stages of the following: Moderate to severe rheumatoid arthritis including acute flares of chronic disease. Moderate to severe ankylosing spondylitis. Moderate to severe osteoarthritis. Acute painful shoulder (bursitis and/or tendinitis). Acute gouty …
Side Effects
Dipyridamole
Indomethacin
Cost Comparison
Dipyridamole
$150–$400/month
Since Dipyridamole is only available as a brand-name drug, look for manufacturer coupons or patient assistance programs to help reduce the cost. Discount cards like GoodRx may also offer savings.
Indomethacin
$30–$80/month
While Indomethacin is available generically, its brand name is also Indomethacin. Using discount cards like GoodRx can often help reduce the cost significantly.
Compare prices for Dipyridamole and Indomethacin
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.