Combining Dipyridamole and Piroxicam is a major interaction and should generally be avoided without close medical supervision.
Combining piroxicam with dipyridamole significantly increases your risk of bleeding, especially from the stomach or intestines. This combination should generally be avoided.
Mechanism: Piroxicam, a non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis and platelet aggregation. Dipyridamole is an antiplatelet agent that inhibits phosphodiesterase, leading to increased cyclic AMP and reduced platelet aggregation. The concurrent use of these agents results in additive antiplatelet effects, significantly impairing hemostasis.
Dipyridamole vs. Piroxicam
Compare Dipyridamole and Piroxicam: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Dipyridamole
Dipyridamole
Antiplatelet Agents
RxDrug B
Piroxicam
Piroxicam
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Dipyridamole | Piroxicam |
|---|---|---|
| Drug Class | Antiplatelet Agents | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $150–$400/month | $10–$30/month |
Dipyridamole Overview
Dipyridamole is a medication that helps prevent blood clots. It works by making platelets, tiny blood cells involved in clotting, less sticky. This medicine is primarily used alongside other blood thinners to prevent dangerous blood clots after heart valve replacement surgery.
Full Dipyridamole guide →Piroxicam Overview
PIROXICAM (brand name: Piroxicam) is a NSAIDs. 1 INDICATIONS AND USAGE Piroxicam capsules are indicated: • For relief of the signs and symptoms of osteoarthritis. • For relief of the signs and symptoms of rheumatoid arthritis. Piroxicam capsules are a nonsteroidal anti-inflammatory drug indicated for •Relief of the signs and symptoms of…
Full Piroxicam guide →How Each Drug Works
Dipyridamole
Mechanism of Action Dipyridamole inhibits the uptake of adenosine into platelets, endothelial cells and erythrocytes in vitro and in vivo ; the inhibition occurs in a dose-dependent manner at therapeutic concentrations (0.5 mcg/mL to 1.9 mcg/mL). This inhibition results in an increase in local concentrations of adenosine which acts on the platelet A 2 -receptor thereby stimulating platelet adenylate cyclase and increasing platelet cyclic-3',5'-adenosine monophosphate (cAMP) levels. Via this mech…
Piroxicam
Piroxicam has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of piroxicam capsules, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Piroxicam is a potent inhibitor of prostaglandin (PG) synthesis in vitro. Piroxicam concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in in…
Approved Uses (Indications)
Dipyridamole
INDICATIONS AND USAGE Dipyridamole tablets are indicated as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement.
Piroxicam
Piroxicam capsules are indicated:
- For relief of the signs and symptoms of osteoarthritis.
- For relief of the signs and symptoms of rheumatoid arthritis. Piroxicam capsules are a nonsteroidal anti-inflammatory drug indicated for
- Relief of the signs and symptoms of osteoarthritis (OA)
- Relief of the signs and symptoms of rheumatoid arthritis (RA)
Side Effects
Dipyridamole
Piroxicam
Cost Comparison
Dipyridamole
$150–$400/month
Since Dipyridamole is only available as a brand-name drug, look for manufacturer coupons or patient assistance programs to help reduce the cost. Discount cards like GoodRx may also offer savings.
Piroxicam
$10–$30/month
Piroxicam is available as an affordable generic. Patients can often find significant savings by using discount cards or coupons from services like GoodRx.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.