Combining Edoxaban Tosylate and Etodolac is a major interaction and should generally be avoided without close medical supervision.
Combining etodolac (an NSAID) with edoxaban (a blood thinner) significantly increases your risk of bleeding, including serious internal bleeding. You should avoid taking these medications together.
Mechanism: Etodolac, a non-steroidal anti-inflammatory drug (NSAID), inhibits prostaglandin synthesis, which can impair gastric mucosal defense and inhibit platelet aggregation. Edoxaban is a direct oral anticoagulant (DOAC) that inhibits Factor Xa, preventing clot formation. The concomitant use of an NSAID and a DOAC results in additive antiplatelet and anticoagulant effects, alongside increased gastrointestinal mucosal damage from the NSAID.
Edoxaban Tosylate vs. Etodolac
Compare Edoxaban Tosylate and Etodolac: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Edoxaban Tosylate
Savaysa
Anticoagulants
RxDrug B
Etodolac
Etodolac
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Edoxaban Tosylate | Etodolac |
|---|---|---|
| Drug Class | Anticoagulants | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $400–$600/month | $15-$60/month |
Edoxaban Tosylate Overview
Savaysa (edoxaban tosylate) is a type of blood thinner that works by blocking a specific clotting factor in your blood. It is prescribed to reduce the risk of stroke and dangerous blood clots in people with a heart condition called nonvalvular atrial fibrillation. Savaysa is also used to treat existing deep vein clots in the legs (DVT) and blood clots in the lungs (PE) after initial treatment with...
Full Edoxaban Tosylate guide →Etodolac Overview
ETODOLAC (brand name: Etodolac) is a NSAIDs. INDICATIONS AND USAGE Carefully consider the potential benefits and risks of etodolac extended-release tablets and other treatment options before deciding to use etodolac extended-release tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment…
Full Etodolac guide →How Each Drug Works
Edoxaban Tosylate
Edoxaban is a selective inhibitor of FXa. It does not require antithrombin III for antithrombotic activity. Edoxaban inhibits free FXa, and prothrombinase activity and inhibits thrombin-induced platelet aggregation. Inhibition of FXa in the coagulation cascade reduces thrombin generation and reduces thrombus formation.
Approved Uses (Indications)
Edoxaban Tosylate
1 INDICATIONS AND USAGE SAVAYSA is a factor Xa inhibitor indicated: To reduce the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF) Limitation of Use for NVAF SAVAYSA should not be used in patients with creatinine clearance (CrCL) > 95 mL/min because of increased risk of ischemic stroke compared to warfarin at the highest dose studied (60 mg) SAVAYSA is indicated for the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) following 5 to 10 days of initial therapy with a parenteral anticoagulant
Reductio…
Etodolac
INDICATIONS AND USAGE Carefully consider the potential benefits and risks of etodolac extended-release tablets and other treatment options before deciding to use etodolac extended-release tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS ). Etodolac extended-release tablets are indicated: * For relief of signs and symptoms of juvenile arthritis * For relief of the signs and symptoms of rheumatoid arthritis * For relief of the signs and symptoms of osteoarthritis
Side Effects
Edoxaban Tosylate
Etodolac
Cost Comparison
Edoxaban Tosylate
$400–$600/month
As SAVAYSA is a brand-name medication, manufacturer coupons or patient assistance programs are often the best ways to reduce out-of-pocket costs. Discount cards like GoodRx may also offer some savings, but manufacturer programs are usually more substantial.
Etodolac
$15-$60/month
Since Etodolac is available as a generic, using discount cards like GoodRx can significantly reduce the cash price. Always compare prices at different pharmacies.
Compare prices for Edoxaban Tosylate and Etodolac
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.