Combining Edoxaban Tosylate and Ibuprofen is a major interaction and should generally be avoided without close medical supervision.
Combining ibuprofen with edoxaban significantly increases your risk of bleeding, especially in the stomach and intestines. This combination should generally be avoided.
Mechanism: Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), inhibits prostaglandin synthesis, which reduces the protective mucosal barrier in the gastrointestinal tract and impairs platelet function. Edoxaban is a direct oral anticoagulant that inhibits Factor Xa, preventing clot formation. The concurrent use of both agents leads to additive antiplatelet and anticoagulant effects, alongside increased gastrointestinal mucosal damage.
Edoxaban Tosylate vs. Ibuprofen
Compare Edoxaban Tosylate and Ibuprofen: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Edoxaban Tosylate
Savaysa
Anticoagulants
RxDrug B
Ibuprofen
good neighbor pharmacy ibuprofen
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Edoxaban Tosylate | Ibuprofen |
|---|---|---|
| Drug Class | Anticoagulants | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $400–$600/month | $4-$15/month |
Edoxaban Tosylate Overview
Savaysa (edoxaban tosylate) is a type of blood thinner that works by blocking a specific clotting factor in your blood. It is prescribed to reduce the risk of stroke and dangerous blood clots in people with a heart condition called nonvalvular atrial fibrillation. Savaysa is also used to treat existing deep vein clots in the legs (DVT) and blood clots in the lungs (PE) after initial treatment with...
Full Edoxaban Tosylate guide →Ibuprofen Overview
IBUPROFEN (brand name: good neighbor pharmacy ibuprofen) is a NSAIDs. Uses • temporarily relieves minor aches and pains due to: • headache • muscular aches • minor pain of arthritis • toothache • backache • the common cold • menstrual cramps • temporarily reduces fever
Full Ibuprofen guide →How Each Drug Works
Edoxaban Tosylate
Edoxaban is a selective inhibitor of FXa. It does not require antithrombin III for antithrombotic activity. Edoxaban inhibits free FXa, and prothrombinase activity and inhibits thrombin-induced platelet aggregation. Inhibition of FXa in the coagulation cascade reduces thrombin generation and reduces thrombus formation.
Approved Uses (Indications)
Edoxaban Tosylate
1 INDICATIONS AND USAGE SAVAYSA is a factor Xa inhibitor indicated: To reduce the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF) Limitation of Use for NVAF SAVAYSA should not be used in patients with creatinine clearance (CrCL) > 95 mL/min because of increased risk of ischemic stroke compared to warfarin at the highest dose studied (60 mg) SAVAYSA is indicated for the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) following 5 to 10 days of initial therapy with a parenteral anticoagulant
Reductio…
Ibuprofen
Uses
- temporarily relieves minor aches and pains due to:
- headache
- muscular aches
- minor pain of arthritis
- toothache
- backache
- the common cold
- menstrual cramps
- temporarily reduces fever
Side Effects
Edoxaban Tosylate
Cost Comparison
Edoxaban Tosylate
$400–$600/month
As SAVAYSA is a brand-name medication, manufacturer coupons or patient assistance programs are often the best ways to reduce out-of-pocket costs. Discount cards like GoodRx may also offer some savings, but manufacturer programs are usually more substantial.
Ibuprofen
$4-$15/month
Ibuprofen is widely available as an inexpensive generic, even without insurance. Discount cards can further reduce the cost at many pharmacies.
Compare prices for Edoxaban Tosylate and Ibuprofen
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.