Combining Edoxaban Tosylate and Meloxicam is a major interaction and should generally be avoided without close medical supervision.
Combining meloxicam with edoxaban significantly increases your risk of bleeding, especially from the stomach or intestines. This combination should generally be avoided.
Mechanism: Meloxicam, a non-steroidal anti-inflammatory drug (NSAID), inhibits prostaglandin synthesis, which can impair gastric mucosal protection and inhibit platelet aggregation. Edoxaban is a direct oral anticoagulant (DOAC) that inhibits Factor Xa, preventing clot formation. The combined effect leads to an additive increase in bleeding risk.
Edoxaban Tosylate vs. Meloxicam
Compare Edoxaban Tosylate and Meloxicam: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Edoxaban Tosylate
Savaysa
Anticoagulants
RxDrug B
Meloxicam
meloxicam
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Edoxaban Tosylate | Meloxicam |
|---|---|---|
| Drug Class | Anticoagulants | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $400–$600/month | $4–$20/month |
Edoxaban Tosylate Overview
Savaysa (edoxaban tosylate) is a type of blood thinner that works by blocking a specific clotting factor in your blood. It is prescribed to reduce the risk of stroke and dangerous blood clots in people with a heart condition called nonvalvular atrial fibrillation. Savaysa is also used to treat existing deep vein clots in the legs (DVT) and blood clots in the lungs (PE) after initial treatment with...
Full Edoxaban Tosylate guide →Meloxicam Overview
MELOXICAM (brand name: meloxicam) is a NSAIDs. 1 INDICATIONS AND USAGE Meloxicam Tablets are non-steroidal anti-inflammatory drug indicated for: Osteoarthritis (OA) ( 1.1 ) Rheumatoid Arthritis (RA) ( 1.2 ) Juvenile Rheumatoid Arthritis (JRA) in patients who weigh ≥ 60 kg ( 1.3 ) 1.1 Osteoarthritis (OA) Meloxicam tablets are indicated for…
Full Meloxicam guide →How Each Drug Works
Edoxaban Tosylate
Edoxaban is a selective inhibitor of FXa. It does not require antithrombin III for antithrombotic activity. Edoxaban inhibits free FXa, and prothrombinase activity and inhibits thrombin-induced platelet aggregation. Inhibition of FXa in the coagulation cascade reduces thrombin generation and reduces thrombus formation.
Meloxicam
Meloxicam has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of meloxicam, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Meloxicam is a potent inhibitor of prostaglandin synthesis in vitro . Meloxicam concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain i…
Approved Uses (Indications)
Edoxaban Tosylate
1 INDICATIONS AND USAGE SAVAYSA is a factor Xa inhibitor indicated: To reduce the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF) Limitation of Use for NVAF SAVAYSA should not be used in patients with creatinine clearance (CrCL) > 95 mL/min because of increased risk of ischemic stroke compared to warfarin at the highest dose studied (60 mg) SAVAYSA is indicated for the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) following 5 to 10 days of initial therapy with a parenteral anticoagulant
Reductio…
Meloxicam
Meloxicam Tablets are non-steroidal anti-inflammatory drug indicated for: Osteoarthritis (OA) Rheumatoid Arthritis (RA) Juvenile Rheumatoid Arthritis (JRA) in patients who weigh ≥ 60 kg 1.1 Osteoarthritis (OA) Meloxicam tablets are indicated for relief of the signs and symptoms of osteoarthritis [see Clinical Studies ]. 1.2 Rheumatoid Arthritis (RA) Meloxicam tablets are indicated for relief of the signs and symptoms of rheumatoid arthritis [see Clinical Studies ].
Juvenile Rheumatoid Arthritis (JRA) Pauciarticular and Polya…
Side Effects
Edoxaban Tosylate
Meloxicam
Cost Comparison
Edoxaban Tosylate
$400–$600/month
As SAVAYSA is a brand-name medication, manufacturer coupons or patient assistance programs are often the best ways to reduce out-of-pocket costs. Discount cards like GoodRx may also offer some savings, but manufacturer programs are usually more substantial.
Meloxicam
$4–$20/month
Meloxicam is available as an inexpensive generic. Patients can significantly reduce costs using discount cards or by checking prices at different pharmacies.
Compare prices for Edoxaban Tosylate and Meloxicam
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.