Combining Edoxaban Tosylate and Piroxicam is a major interaction and should generally be avoided without close medical supervision.
Combining piroxicam with edoxaban significantly increases your risk of serious bleeding, including stomach bleeding. You should avoid this combination unless specifically instructed by your doctor, who will weigh the risks carefully.
Mechanism: Piroxicam, a non-selective NSAID, inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis and impairing platelet aggregation. Edoxaban is a direct oral anticoagulant (DOAC) that inhibits Factor Xa, preventing thrombin generation and clot formation. The concurrent use of these agents results in an additive antiplatelet and anticoagulant effect, profoundly increasing the risk of hemorrhage.
Edoxaban Tosylate vs. Piroxicam
Compare Edoxaban Tosylate and Piroxicam: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Edoxaban Tosylate
Savaysa
Anticoagulants
RxDrug B
Piroxicam
Piroxicam
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Edoxaban Tosylate | Piroxicam |
|---|---|---|
| Drug Class | Anticoagulants | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $400–$600/month | $10–$30/month |
Edoxaban Tosylate Overview
Savaysa (edoxaban tosylate) is a type of blood thinner that works by blocking a specific clotting factor in your blood. It is prescribed to reduce the risk of stroke and dangerous blood clots in people with a heart condition called nonvalvular atrial fibrillation. Savaysa is also used to treat existing deep vein clots in the legs (DVT) and blood clots in the lungs (PE) after initial treatment with...
Full Edoxaban Tosylate guide →Piroxicam Overview
PIROXICAM (brand name: Piroxicam) is a NSAIDs. 1 INDICATIONS AND USAGE Piroxicam capsules are indicated: • For relief of the signs and symptoms of osteoarthritis. • For relief of the signs and symptoms of rheumatoid arthritis. Piroxicam capsules are a nonsteroidal anti-inflammatory drug indicated for •Relief of the signs and symptoms of…
Full Piroxicam guide →How Each Drug Works
Edoxaban Tosylate
Edoxaban is a selective inhibitor of FXa. It does not require antithrombin III for antithrombotic activity. Edoxaban inhibits free FXa, and prothrombinase activity and inhibits thrombin-induced platelet aggregation. Inhibition of FXa in the coagulation cascade reduces thrombin generation and reduces thrombus formation.
Piroxicam
Piroxicam has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of piroxicam capsules, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Piroxicam is a potent inhibitor of prostaglandin (PG) synthesis in vitro. Piroxicam concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in in…
Approved Uses (Indications)
Edoxaban Tosylate
1 INDICATIONS AND USAGE SAVAYSA is a factor Xa inhibitor indicated: To reduce the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF) Limitation of Use for NVAF SAVAYSA should not be used in patients with creatinine clearance (CrCL) > 95 mL/min because of increased risk of ischemic stroke compared to warfarin at the highest dose studied (60 mg) SAVAYSA is indicated for the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) following 5 to 10 days of initial therapy with a parenteral anticoagulant
Reductio…
Piroxicam
Piroxicam capsules are indicated:
- For relief of the signs and symptoms of osteoarthritis.
- For relief of the signs and symptoms of rheumatoid arthritis. Piroxicam capsules are a nonsteroidal anti-inflammatory drug indicated for
- Relief of the signs and symptoms of osteoarthritis (OA)
- Relief of the signs and symptoms of rheumatoid arthritis (RA)
Side Effects
Edoxaban Tosylate
Piroxicam
Cost Comparison
Edoxaban Tosylate
$400–$600/month
As SAVAYSA is a brand-name medication, manufacturer coupons or patient assistance programs are often the best ways to reduce out-of-pocket costs. Discount cards like GoodRx may also offer some savings, but manufacturer programs are usually more substantial.
Piroxicam
$10–$30/month
Piroxicam is available as an affordable generic. Patients can often find significant savings by using discount cards or coupons from services like GoodRx.
Compare prices for Edoxaban Tosylate and Piroxicam
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.