Combining Enoxaparin Sodium and Indomethacin is a major interaction and should generally be avoided without close medical supervision.
Combining indomethacin with enoxaparin significantly increases your risk of serious bleeding, including stomach bleeding. Your doctor will likely avoid this combination or monitor you very closely.
Mechanism: Indomethacin, an NSAID, inhibits prostaglandin synthesis, which reduces platelet aggregation and can damage the gastrointestinal mucosa, increasing bleeding risk. Enoxaparin is a low molecular weight heparin that directly inhibits Factor Xa, preventing clot formation. The additive antiplatelet effect of indomethacin and the anticoagulant effect of enoxaparin lead to a synergistic increase in bleeding risk.
Enoxaparin Sodium vs. Indomethacin
Compare Enoxaparin Sodium and Indomethacin: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Enoxaparin Sodium
Enoxaparin Sodium
Anticoagulants
RxDrug B
Indomethacin
Indomethacin
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Enoxaparin Sodium | Indomethacin |
|---|---|---|
| Drug Class | Anticoagulants | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $150-$600/month | $30–$80/month |
Enoxaparin Sodium Overview
Enoxaparin Sodium is a type of medicine known as a blood thinner, specifically a low molecular weight heparin. It works by helping to prevent and treat dangerous blood clots, such as those that can form in the legs (deep vein thrombosis or DVT) or travel to the lungs (pulmonary embolism). This medication is also used to help manage certain heart conditions like unstable angina or heart attacks.
Full Enoxaparin Sodium guide →Indomethacin Overview
INDOMETHACIN (brand name: Indomethacin) is a NSAIDs. INDICATIONS AND USAGE Carefully consider the potential benefits and risks of indomethacin capsules and other treatment options before deciding to use indomethacin. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS ).…
Full Indomethacin guide →How Each Drug Works
Enoxaparin Sodium
Enoxaparin is a low molecular weight heparin which has antithrombotic properties.
Approved Uses (Indications)
Enoxaparin Sodium
Enoxaparin Sodium Injection is a low molecular weight heparin (LMWH) indicated for: Prophylaxis of deep vein thrombosis (DVT) in abdominal surgery, hip replacement surgery, knee replacement surgery, or medical patients with severely restricted mobility during acute illness Inpatient treatment of acute DVT with or without pulmonary embolism Outpatient treatment of acute DVT without pulmonary embolism Prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction (MI) Treatment of acute ST-segment elevation my…
Indomethacin
INDICATIONS AND USAGE Carefully consider the potential benefits and risks of indomethacin capsules and other treatment options before deciding to use indomethacin. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS ). Indomethacin Capsule, USP has been found effective in active stages of the following: Moderate to severe rheumatoid arthritis including acute flares of chronic disease. Moderate to severe ankylosing spondylitis. Moderate to severe osteoarthritis. Acute painful shoulder (bursitis and/or tendinitis). Acute gouty …
Side Effects
Enoxaparin Sodium
Indomethacin
Cost Comparison
Enoxaparin Sodium
$150-$600/month
As a generic, enoxaparin sodium is much more affordable than its brand-name counterpart. Using discount cards like GoodRx can further reduce the cost significantly.
Indomethacin
$30–$80/month
While Indomethacin is available generically, its brand name is also Indomethacin. Using discount cards like GoodRx can often help reduce the cost significantly.
Compare prices for Enoxaparin Sodium and Indomethacin
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.