Combining Enoxaparin Sodium and Naproxen is a major interaction and should generally be avoided without close medical supervision.
Combining naproxen with enoxaparin significantly increases your risk of bleeding, which can be serious or even life-threatening. This includes bleeding from the stomach, intestines, or other body parts.
Mechanism: Naproxen, an NSAID, inhibits cyclooxygenase (COX) enzymes, leading to reduced prostaglandin synthesis and impaired platelet aggregation. Enoxaparin is a low molecular weight heparin that directly inhibits Factor Xa, preventing clot formation. The concurrent use results in an additive antiplatelet and anticoagulant effect, profoundly increasing the risk of hemorrhage.
Enoxaparin Sodium vs. Naproxen
Compare Enoxaparin Sodium and Naproxen: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Enoxaparin Sodium
Enoxaparin Sodium
Anticoagulants
RxDrug B
Naproxen
Naproxen
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxQuick Comparison
| Category | Enoxaparin Sodium | Naproxen |
|---|---|---|
| Drug Class | Anticoagulants | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $150-$600/month | $4–$25/month |
Enoxaparin Sodium Overview
Enoxaparin Sodium is a type of medicine known as a blood thinner, specifically a low molecular weight heparin. It works by helping to prevent and treat dangerous blood clots, such as those that can form in the legs (deep vein thrombosis or DVT) or travel to the lungs (pulmonary embolism). This medication is also used to help manage certain heart conditions like unstable angina or heart attacks.
Full Enoxaparin Sodium guide →Naproxen Overview
NAPROXEN (brand name: Naproxen) is a NSAIDs. 1 INDICATIONS & USAGE Naproxen delayed-release tablets are indicated for: the relief of the signs and symptoms of: rheumatoid arthritis osteoarthritis ankylosing spondylitis Polyarticular Juvenile Idiopathic Arthritis Naproxen delayed-release tablets are non-steroidal anti-inflammatory drugs…
Full Naproxen guide →How Each Drug Works
Enoxaparin Sodium
Enoxaparin is a low molecular weight heparin which has antithrombotic properties.
Naproxen
Naproxen has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of naproxen, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Naproxen is a potent inhibitor of prostaglandin synthesis in vitro. Naproxen concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in ani…
Approved Uses (Indications)
Enoxaparin Sodium
Enoxaparin Sodium Injection is a low molecular weight heparin (LMWH) indicated for: Prophylaxis of deep vein thrombosis (DVT) in abdominal surgery, hip replacement surgery, knee replacement surgery, or medical patients with severely restricted mobility during acute illness Inpatient treatment of acute DVT with or without pulmonary embolism Outpatient treatment of acute DVT without pulmonary embolism Prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction (MI) Treatment of acute ST-segment elevation my…
Naproxen
Naproxen delayed-release tablets are indicated for: the relief of the signs and symptoms of: rheumatoid arthritis osteoarthritis ankylosing spondylitis Polyarticular Juvenile Idiopathic Arthritis Naproxen delayed-release tablets are non-steroidal anti-inflammatory drugs indicated for: the relief of the signs and symptoms of: rheumatoid arthritis osteoarthritis ankylosing spondylitis polyarticular juvenile idiopathic arthritis
Side Effects
Enoxaparin Sodium
Naproxen
Cost Comparison
Enoxaparin Sodium
$150-$600/month
As a generic, enoxaparin sodium is much more affordable than its brand-name counterpart. Using discount cards like GoodRx can further reduce the cost significantly.
Naproxen
$4–$25/month
Naproxen is widely available as an affordable generic. Using discount cards like GoodRx can further reduce the cost, often bringing it to under $10 per month.
Compare prices for Enoxaparin Sodium and Naproxen
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.