Escitalopram Oxalate and Tranylcypromine Sulfate must not be used together. This combination is classified as CONTRAINDICATED.
Co-administration of escitalopram and tranylcypromine is absolutely contraindicated due to a severe and potentially fatal risk of serotonin syndrome. Symptoms can include mental status changes, autonomic instability, neuromuscular abnormalities, and gastrointestinal symptoms.
Mechanism: Escitalopram increases serotonin levels by inhibiting its reuptake, while tranylcypromine, a non-selective MAOI, prevents the metabolic breakdown of serotonin. The combined effect leads to excessive serotonergic activity in the central nervous system.
Escitalopram Oxalate vs. Tranylcypromine Sulfate
Compare Escitalopram Oxalate and Tranylcypromine Sulfate: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Escitalopram Oxalate
Escitalopram
SSRIs (Selective Serotonin Reuptake Inhibitors)
RxDrug B
Tranylcypromine Sulfate
Parnate
MAOIs (Monoamine Oxidase Inhibitors)
RxQuick Comparison
| Category | Escitalopram Oxalate | Tranylcypromine Sulfate |
|---|---|---|
| Drug Class | SSRIs (Selective Serotonin Reuptake Inhibitors) | MAOIs (Monoamine Oxidase Inhibitors) |
| Rx Status | Rx | Rx |
| Generic Available | No | Yes |
| Typical Cost | $4–$25/month | $30-$80/month |
Escitalopram Oxalate Overview
Escitalopram is a type of antidepressant medication called a selective serotonin reuptake inhibitor (SSRI). It is used to treat major depressive disorder and generalized anxiety disorder by helping to restore the balance of a natural substance called serotonin in the brain.
Full Escitalopram Oxalate guide →Tranylcypromine Sulfate Overview
TRANYLCYPROMINE SULFATE (brand name: PARNATE) is a MAOIs. 1 INDICATIONS AND USAGE PARNATE is indicated for the treatment of major depressive disorder (MDD) in adult patients who have not responded adequately to other antidepressants. PARNATE is not indicated for the initial treatment of MDD due to the potential for serious adverse reactions and drug…
Full Tranylcypromine Sulfate guide →How Each Drug Works
Escitalopram Oxalate
The mechanism of antidepressant action of escitalopram, the S-enantiomer of racemic citalopram, is presumed to be linked to potentiation of serotonergic activity in the central nervous system (CNS) resulting from its inhibition of CNS neuronal reuptake of serotonin (5-HT).
Tranylcypromine Sulfate
The mechanism of action of PARNATE as an antidepressant is not fully understood, but is presumed to be linked to potentiation of monoamine neurotransmitter activity in the central nervous system (CNS) resulting from its irreversible inhibition of the enzyme monoamine oxidase (MAO).
Approved Uses (Indications)
Escitalopram Oxalate
Escitalopram tablets are indicated for the treatment of: major depressive disorder (MDD) in adults and pediatric patients 12 years of age and older. generalized anxiety disorder (GAD) inadults. Additional pediatric use information is approved for AbbVie Inc.’s LEXAPRO (escitalopram) tablets. However, due to AbbVie Inc.’s marketing exclusivity rights, this drug product is not labeled with that information. Escitalopram oxalate is a selective serotonin reuptake inhibitor (SSRI) indicated for the: treatment of major depressive disorder (MDD) in adults and pediatric patient…
Tranylcypromine Sulfate
1 INDICATIONS AND USAGE PARNATE is indicated for the treatment of major depressive disorder (MDD) in adult patients who have not responded adequately to other antidepressants. PARNATE is not indicated for the initial treatment of MDD due to the potential for serious adverse reactions and drug interactions, and the need for dietary restrictions [ see Contraindications , Warnings and Precautions , and Drug Interactions ] . PARNATE is a monoamine oxidase inhibitor (MAOI) indicated for the treatment of major depressive disorder (MDD) in adult patients who have not responded adequately …
Side Effects
Escitalopram Oxalate
Tranylcypromine Sulfate
Cost Comparison
Escitalopram Oxalate
$4–$25/month
As a widely available generic, escitalopram is very affordable. Patients can often find it for under $10 a month using discount cards like GoodRx or through pharmacy savings programs.
Tranylcypromine Sulfate
$30-$80/month
Generic available
Generic tranylcypromine is available and generally more affordable than the brand name Parnate. Prices can vary based on pharmacy, dosage, and insurance coverage. Manufacturer coupons or patient assistance programs may be available.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.