Fentanyl and Oxazepam must not be used together. This combination is classified as CONTRAINDICATED.
Concomitant use significantly increases the risk of severe respiratory depression, profound sedation, coma, and death. Patients may experience decreased respiratory rate, shallow breathing, hypoxemia, unresponsiveness, and circulatory collapse.
Mechanism: Fentanyl, an opioid agonist, and oxazepam, a benzodiazepine, both exert central nervous system (CNS) depressant effects. The co-administration leads to additive pharmacodynamic depression of the CNS, particularly affecting the respiratory drive and level of consciousness.
Fentanyl vs. Oxazepam
Compare Fentanyl and Oxazepam: mechanism of action, indications, side effects, cost, and which may be right for you.
Quick Comparison
| Category | Fentanyl | Oxazepam |
|---|---|---|
| Drug Class | Opioid Analgesics | Benzodiazepines |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $150–$600/month | $15–$50/month |
Fentanyl Overview
FENTANYL (brand name: FENTANYL) is a Opioid Analgesics. 1 INDICATIONS AND USAGE Fentanyl transdermal system is indicated for the management of severe and persistent pain in opioid-tolerant patients, that requires an opioid analgesic and that cannot be adequately treated with alternative options, including immediate-release opioids. Patients considered…
Full Fentanyl guide →Oxazepam Overview
OXAZEPAM (brand name: Oxazepam) is a Benzodiazepines. used to treat anxiety disorders, insomnia, seizures, and alcohol withdrawal.
Full Oxazepam guide →How Each Drug Works
Fentanyl
Fentanyl is an opioid agonist. Fentanyl interacts predominately with the opioid mu-receptor. These mu-binding sites are distributed in the human brain, spinal cord, and other tissues.
Approved Uses (Indications)
Fentanyl
Fentanyl transdermal system is indicated for the management of severe and persistent pain in opioid-tolerant patients, that requires an opioid analgesic and that cannot be adequately treated with alternative options, including immediate-release opioids. Patients considered opioid-tolerant are those who are taking, for one week or longer, at least 60 mg morphine per day, 25 mcg transdermal fentanyl per hour, 30 mg oral oxycodone per day, 8 mg oral hydromorphone per day, 25 mg oral oxymorphone per day, 60 mg oral hydrocodone per day, or an equianalgesic dose of another op…
Side Effects
Fentanyl
Oxazepam
Cost Comparison
Fentanyl
$150–$600/month
As a brand-only medication, fentanyl can be expensive. Patients should check for manufacturer coupons or patient assistance programs, and compare prices at different pharmacies using discount cards.
Oxazepam
$15–$50/month
As a generic medication, Oxazepam is relatively affordable. Patients can often find significant savings by using discount cards or checking prices at different pharmacies.
Compare prices for Fentanyl and Oxazepam
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.