Combining Fluoxetine HCl and Metoprolol Succinate is a major interaction and should generally be avoided without close medical supervision.
Fluoxetine, a potent CYP2D6 inhibitor, can significantly increase plasma concentrations of metoprolol, a CYP2D6-metabolized beta-blocker. This can lead to an increased risk of adverse effects such as severe bradycardia, hypotension, and heart block.
Mechanism: Fluoxetine inhibits the cytochrome P450 2D6 (CYP2D6) enzyme, which is primarily responsible for the metabolism of metoprolol. This pharmacokinetic interaction reduces metoprolol clearance, leading to higher systemic exposure.
Fluoxetine HCl vs. Metoprolol Succinate
Compare Fluoxetine HCl and Metoprolol Succinate: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Fluoxetine HCl
Fluoxetine HCL
SSRIs (Selective Serotonin Reuptake Inhibitors)
RxDrug B
Metoprolol Succinate
Metoprolol Succinate
Beta-Blockers
RxQuick Comparison
| Category | Fluoxetine HCl | Metoprolol Succinate |
|---|---|---|
| Drug Class | SSRIs (Selective Serotonin Reuptake Inhibitors) | Beta-Blockers |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $4-$25/month | $4-$25/month |
Fluoxetine HCl Overview
FLUOXETINE HCL (brand name: Fluoxetine HCL) is a SSRIs. Fluoxetine is indicated for the treatment of: Acute and maintenance treatment of Major Depressive Disorder [see CLINICAL STUDIES (14.1)] . Acute and maintenance treatment of obsessions and compulsions in patients with Obsessive Compulsive Disorder (OCD) [see CLINICAL STUDIES (14.2)] . Acute and…
Full Fluoxetine HCl guide →Metoprolol Succinate Overview
METOPROLOL SUCCINATE (brand name: Metoprolol Succinate) is a Beta-Blockers. 1 INDICATIONS & USAGE Metoprolol succinate extended-release tablets, metoprolol succinate, beta-adrenergic blocker indicated for the treatment of: • Hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and…
Full Metoprolol Succinate guide →Approved Uses (Indications)
Fluoxetine HCl
Fluoxetine is indicated for the treatment of: Acute and maintenance treatment of Major Depressive Disorder [see CLINICAL STUDIES ] . Acute and maintenance treatment of obsessions and compulsions in patients with Obsessive Compulsive Disorder (OCD) [see CLINICAL STUDIES ] . Acute and maintenance treatment of binge-eating and vomiting behaviors in patients with moderate to severe Bulimia Nervosa [see CLINICAL STUDIES ] . Acute treatment of Panic Disorder, with or without agoraphobia [see CLINICAL STUDIES ] . Fluoxetine and Olanzapine in Combination is indicated for the tr…
Metoprolol Succinate
Metoprolol succinate extended-release tablets, metoprolol succinate, beta-adrenergic blocker indicated for the treatment of:
- Hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.()
- Angina Pectoris. ()
- Heart Failure, to reduce the risk of cardiovascular mortality and heart failure hospitalizations in patients with heart failure() 1.1 Hypertension Metoprolol succinate extended-release tablets is indicated for the treatment of hypertension, to lower blo…
Side Effects
Fluoxetine HCl
Metoprolol Succinate
Cost Comparison
Fluoxetine HCl
$4-$25/month
As a widely available generic, Fluoxetine HCl is very affordable. Patients can often find significant savings using discount cards or by checking prices at different pharmacies.
Metoprolol Succinate
$4-$25/month
Metoprolol Succinate is available as a low-cost generic. Patients can often find significant savings by using discount cards or patient assistance programs.
Compare prices for Fluoxetine HCl and Metoprolol Succinate
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Medical Disclaimer
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