Drug Comparison

Fluoxetine HCl vs. Metoprolol Tartrate

Compare Fluoxetine HCl and Metoprolol Tartrate: mechanism of action, indications, side effects, cost, and which may be right for you.

Quick Comparison

CategoryFluoxetine HClMetoprolol Tartrate
Drug ClassSSRIs (Selective Serotonin Reuptake Inhibitors)Beta-Blockers
Rx StatusRxRx
Generic AvailableNoNo
Typical Cost$4-$25/month$4–$25/month

Fluoxetine HCl Overview

FLUOXETINE HCL (brand name: Fluoxetine HCL) is a SSRIs. Fluoxetine is indicated for the treatment of: Acute and maintenance treatment of Major Depressive Disorder [see CLINICAL STUDIES (14.1)] . Acute and maintenance treatment of obsessions and compulsions in patients with Obsessive Compulsive Disorder (OCD) [see CLINICAL STUDIES (14.2)] . Acute and…

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Metoprolol Tartrate Overview

Metoprolol Tartrate is a beta-blocker medication used to treat high blood pressure, chest pain (angina), and to improve outcomes after a heart attack. It works by relaxing blood vessels and slowing the heart rate, which helps to lower blood pressure and reduce the heart's workload.

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Approved Uses (Indications)

Fluoxetine HCl

Fluoxetine is indicated for the treatment of: Acute and maintenance treatment of Major Depressive Disorder [see CLINICAL STUDIES ] . Acute and maintenance treatment of obsessions and compulsions in patients with Obsessive Compulsive Disorder (OCD) [see CLINICAL STUDIES ] . Acute and maintenance treatment of binge-eating and vomiting behaviors in patients with moderate to severe Bulimia Nervosa [see CLINICAL STUDIES ] . Acute treatment of Panic Disorder, with or without agoraphobia [see CLINICAL STUDIES ] . Fluoxetine and Olanzapine in Combination is indicated for the tr…

Metoprolol Tartrate

Metoprolol tartrate is a beta-adrenergic blocker indicated for the treatment of:

  • Hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.
  • Angina Pectoris.
  • Myocardial Infarction, to reduce the risk of cardiovascular mortality when used in conjunction with intravenous metoprolol therapy in patients with definite or suspected acute myocardial infarction in hemodynamically stable patients.

Hypertension Metoprolol tartrate is in…

Side Effects

Fluoxetine HCl

Metoprolol Tartrate

Cost Comparison

Fluoxetine HCl

$4-$25/month

As a widely available generic, Fluoxetine HCl is very affordable. Patients can often find significant savings using discount cards or by checking prices at different pharmacies.

Metoprolol Tartrate

$4–$25/month

As a widely available generic, Metoprolol Tartrate is typically affordable. Using discount cards like GoodRx can further reduce the cost, often bringing it down to under $10 per month at many pharmacies.

Drug Interaction: Moderate

Fluoxetine significantly increases metoprolol plasma levels through CYP2D6 inhibition, increasing the risk of bradycardia and heart block.

Mechanism: Fluoxetine is a potent CYP2D6 inhibitor. Metoprolol is primarily metabolized by CYP2D6; inhibition increases metoprolol AUC by 3–5 fold.

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Medical Disclaimer

The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.