Combining Fluoxetine HCl and Nebivolol is a major interaction and should generally be avoided without close medical supervision.
Concomitant use of nebivolol and fluoxetine can significantly increase nebivolol plasma concentrations, leading to enhanced beta-blockade effects. This can manifest as severe bradycardia, hypotension, and potentially heart block, increasing the risk of cardiovascular adverse events.
Mechanism: Fluoxetine is a potent inhibitor of the cytochrome P450 2D6 (CYP2D6) enzyme. Nebivolol is primarily metabolized by CYP2D6, so fluoxetine inhibits its metabolism, leading to elevated systemic exposure to nebivolol.
Fluoxetine HCl vs. Nebivolol
Compare Fluoxetine HCl and Nebivolol: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Fluoxetine HCl
Fluoxetine HCL
SSRIs (Selective Serotonin Reuptake Inhibitors)
RxDrug B
Nebivolol
Nebivolol
Beta-Blockers
RxQuick Comparison
| Category | Fluoxetine HCl | Nebivolol |
|---|---|---|
| Drug Class | SSRIs (Selective Serotonin Reuptake Inhibitors) | Beta-Blockers |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $4-$25/month | $200–$500/month |
Fluoxetine HCl Overview
FLUOXETINE HCL (brand name: Fluoxetine HCL) is a SSRIs. Fluoxetine is indicated for the treatment of: Acute and maintenance treatment of Major Depressive Disorder [see CLINICAL STUDIES (14.1)] . Acute and maintenance treatment of obsessions and compulsions in patients with Obsessive Compulsive Disorder (OCD) [see CLINICAL STUDIES (14.2)] . Acute and…
Full Fluoxetine HCl guide →Nebivolol Overview
Nebivolol is a beta-blocker medication used to treat high blood pressure (hypertension). By helping to relax blood vessels and slow the heart rate, it lowers blood pressure, which in turn reduces the risk of serious heart problems like strokes and heart attacks.
Full Nebivolol guide →How Each Drug Works
Nebivolol
The mechanism of action of the antihypertensive response of nebivolol has not been definitively established. Possible factors that may be involved include: decreased heart rate, decreased myocardial contractility, diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers, suppression of renin activity and vasodilation and decreased peripheral vascular resistance.
Approved Uses (Indications)
Fluoxetine HCl
Fluoxetine is indicated for the treatment of: Acute and maintenance treatment of Major Depressive Disorder [see CLINICAL STUDIES ] . Acute and maintenance treatment of obsessions and compulsions in patients with Obsessive Compulsive Disorder (OCD) [see CLINICAL STUDIES ] . Acute and maintenance treatment of binge-eating and vomiting behaviors in patients with moderate to severe Bulimia Nervosa [see CLINICAL STUDIES ] . Acute treatment of Panic Disorder, with or without agoraphobia [see CLINICAL STUDIES ] . Fluoxetine and Olanzapine in Combination is indicated for the tr…
Nebivolol
Nebivolol Tablets are a beta-adrenergic blocking agent indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. 1.1 Hypertension Nebivolol tablets are indicated for the treatment of hypertension, to lower blood pressure [see Clinical Studies ] . Nebivolol tablets may be used alone or in combination with other antihypertensive agents [see Drug Interactions ] . Lowering blood pressure reduces the risk of fata…
Side Effects
Fluoxetine HCl
Nebivolol
Cost Comparison
Fluoxetine HCl
$4-$25/month
As a widely available generic, Fluoxetine HCl is very affordable. Patients can often find significant savings using discount cards or by checking prices at different pharmacies.
Nebivolol
$200–$500/month
Since Nebivolol does not have a generic version, look for manufacturer coupons or patient assistance programs to significantly reduce the cost. Discount cards may also offer some savings.
Compare prices for Fluoxetine HCl and Nebivolol
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.