Drug Comparison

Fluoxetine HCl vs. Pindolol

Compare Fluoxetine HCl and Pindolol: mechanism of action, indications, side effects, cost, and which may be right for you.

Quick Comparison

CategoryFluoxetine HClPindolol
Drug ClassSSRIs (Selective Serotonin Reuptake Inhibitors)Beta-Blockers
Rx StatusRxRx
Generic AvailableNoNo
Typical Cost$4-$25/month$200–$400/month

Fluoxetine HCl Overview

FLUOXETINE HCL (brand name: Fluoxetine HCL) is a SSRIs. Fluoxetine is indicated for the treatment of: Acute and maintenance treatment of Major Depressive Disorder [see CLINICAL STUDIES (14.1)] . Acute and maintenance treatment of obsessions and compulsions in patients with Obsessive Compulsive Disorder (OCD) [see CLINICAL STUDIES (14.2)] . Acute and…

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Pindolol Overview

Pindolol is a type of medicine called a beta-blocker, used to treat high blood pressure (hypertension). It works by helping to relax blood vessels and slow the heart rate, making it easier for your heart to pump blood. This helps to lower your blood pressure and reduce the strain on your heart.

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Approved Uses (Indications)

Fluoxetine HCl

Fluoxetine is indicated for the treatment of: Acute and maintenance treatment of Major Depressive Disorder [see CLINICAL STUDIES ] . Acute and maintenance treatment of obsessions and compulsions in patients with Obsessive Compulsive Disorder (OCD) [see CLINICAL STUDIES ] . Acute and maintenance treatment of binge-eating and vomiting behaviors in patients with moderate to severe Bulimia Nervosa [see CLINICAL STUDIES ] . Acute treatment of Panic Disorder, with or without agoraphobia [see CLINICAL STUDIES ] . Fluoxetine and Olanzapine in Combination is indicated for the tr…

Pindolol

INDICATIONS AND USAGE Pindolol tablets are indicated in the management of hypertension. It may be used alone or concomitantly with other antihypertensive agents, particularly with a thiazide-type diuretic.

Side Effects

Fluoxetine HCl

Pindolol

Cost Comparison

Fluoxetine HCl

$4-$25/month

As a widely available generic, Fluoxetine HCl is very affordable. Patients can often find significant savings using discount cards or by checking prices at different pharmacies.

Pindolol

$200–$400/month

Since Pindolol is only available as a brand-name drug, look for manufacturer coupons or patient assistance programs to help reduce the cost. Discount cards may also offer some savings.

Drug Interaction: Moderate

Fluoxetine can increase pindolol plasma levels, potentially leading to enhanced beta-blockade effects such as bradycardia, hypotension, and heart block. This interaction is due to fluoxetine's potent inhibition of CYP2D6, an enzyme involved in pindolol metabolism.

Mechanism: Fluoxetine is a potent inhibitor of cytochrome P450 2D6 (CYP2D6). Pindolol is partially metabolized by CYP2D6, so fluoxetine can decrease its metabolism and increase its systemic exposure.

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Medical Disclaimer

The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.