Combining Fluoxetine HCl and Propranolol Hydrochloride is a major interaction and should generally be avoided without close medical supervision.
Fluoxetine, a potent CYP2D6 inhibitor, can significantly increase plasma concentrations of propranolol, a beta-blocker primarily metabolized by CYP2D6. This interaction can lead to enhanced beta-blockade effects, manifesting as severe bradycardia, hypotension, or heart block.
Mechanism: Fluoxetine inhibits the cytochrome P450 2D6 (CYP2D6) enzyme, which is a major metabolic pathway for propranolol. This inhibition reduces the clearance of propranolol, leading to elevated systemic exposure and increased pharmacodynamic effects.
Fluoxetine HCl vs. Propranolol Hydrochloride
Compare Fluoxetine HCl and Propranolol Hydrochloride: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Fluoxetine HCl
Fluoxetine HCL
SSRIs (Selective Serotonin Reuptake Inhibitors)
RxDrug B
Propranolol Hydrochloride
propranolol hydrochloride
Beta-Blockers
RxQuick Comparison
| Category | Fluoxetine HCl | Propranolol Hydrochloride |
|---|---|---|
| Drug Class | SSRIs (Selective Serotonin Reuptake Inhibitors) | Beta-Blockers |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $4-$25/month | $30-$100/month |
Fluoxetine HCl Overview
FLUOXETINE HCL (brand name: Fluoxetine HCL) is a SSRIs. Fluoxetine is indicated for the treatment of: Acute and maintenance treatment of Major Depressive Disorder [see CLINICAL STUDIES (14.1)] . Acute and maintenance treatment of obsessions and compulsions in patients with Obsessive Compulsive Disorder (OCD) [see CLINICAL STUDIES (14.2)] . Acute and…
Full Fluoxetine HCl guide →Propranolol Hydrochloride Overview
Propranolol hydrochloride is a medication that helps manage conditions like high blood pressure, chest pain (angina), and prevents migraine headaches. It works by affecting certain signals in the body, which helps to slow the heart rate and relax blood vessels, making it easier for the heart to pump blood.
Full Propranolol Hydrochloride guide →How Each Drug Works
Propranolol Hydrochloride
Mechanism of Action The mechanism of the antihypertensive effect of propranolol has not been established. Among the factors that may be involved in contributing to the antihypertensive action include: decreased cardiac output, inhibition of renin release by the kidneys, and diminution of tonic sympathetic nerve outflow from vasomotor centers in the brain. Although total peripheral resistance may increase initially, it readjusts to or below the pretreatment level with chronic use of p…
Approved Uses (Indications)
Fluoxetine HCl
Fluoxetine is indicated for the treatment of: Acute and maintenance treatment of Major Depressive Disorder [see CLINICAL STUDIES ] . Acute and maintenance treatment of obsessions and compulsions in patients with Obsessive Compulsive Disorder (OCD) [see CLINICAL STUDIES ] . Acute and maintenance treatment of binge-eating and vomiting behaviors in patients with moderate to severe Bulimia Nervosa [see CLINICAL STUDIES ] . Acute treatment of Panic Disorder, with or without agoraphobia [see CLINICAL STUDIES ] . Fluoxetine and Olanzapine in Combination is indicated for the tr…
Propranolol Hydrochloride
INDICATIONS AND USAGE Hypertension Propranolol Hydrochloride Extended-Release Capsules, USP, are indicated in the management of hypertension. They may be used alone or used in combination with other antihypertensive agents, particularly a thiazide diuretic. Propranolol Hydrochloride Extended-Release Capsules, USP, are not indicated in the management of hypertensive emergencies. Angina Pectoris Due to Coronary Atherosclerosis Propranolol Hydrochloride Extended-Release Capsules, USP, are indicated to decrease angina frequency and increase exercise tolerance in patients with angina pectoris. Migr…
Side Effects
Fluoxetine HCl
Propranolol Hydrochloride
Cost Comparison
Fluoxetine HCl
$4-$25/month
As a widely available generic, Fluoxetine HCl is very affordable. Patients can often find significant savings using discount cards or by checking prices at different pharmacies.
Propranolol Hydrochloride
$30-$100/month
Despite the drug being listed as 'brand' in the prompt, Propranolol Hydrochloride is widely available as a generic. Look for generic versions to significantly reduce costs, and consider using discount cards like GoodRx.
Compare prices for Fluoxetine HCl and Propranolol Hydrochloride
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.