Combining Fluoxetine HCl and Timolol Maleate is a major interaction and should generally be avoided without close medical supervision.
The co-administration of timolol, a beta-blocker primarily metabolized by CYP2D6, with fluoxetine, a potent CYP2D6 inhibitor, can significantly increase timolol plasma concentrations. This interaction can lead to exaggerated beta-blockade effects, including severe bradycardia, hypotension, and heart block, particularly given timolol's systemic absorption even when administered topically.
Mechanism: Fluoxetine is a potent inhibitor of the cytochrome P450 2D6 (CYP2D6) enzyme. Timolol is primarily metabolized by CYP2D6, so fluoxetine inhibits the metabolism of timolol, leading to decreased clearance and increased systemic exposure of timolol.
Fluoxetine HCl vs. Timolol Maleate
Compare Fluoxetine HCl and Timolol Maleate: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Fluoxetine HCl
Fluoxetine HCL
SSRIs (Selective Serotonin Reuptake Inhibitors)
RxDrug B
Timolol Maleate
Timolol Maleate
Beta-Blockers
RxQuick Comparison
| Category | Fluoxetine HCl | Timolol Maleate |
|---|---|---|
| Drug Class | SSRIs (Selective Serotonin Reuptake Inhibitors) | Beta-Blockers |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $4-$25/month | $50–$150/month |
Fluoxetine HCl Overview
FLUOXETINE HCL (brand name: Fluoxetine HCL) is a SSRIs. Fluoxetine is indicated for the treatment of: Acute and maintenance treatment of Major Depressive Disorder [see CLINICAL STUDIES (14.1)] . Acute and maintenance treatment of obsessions and compulsions in patients with Obsessive Compulsive Disorder (OCD) [see CLINICAL STUDIES (14.2)] . Acute and…
Full Fluoxetine HCl guide →Timolol Maleate Overview
Timolol Maleate is an eye drop medication used to treat high pressure inside the eye. It works by helping to reduce the amount of fluid your eye produces, which in turn lowers the pressure. This medication is primarily prescribed for conditions like ocular hypertension and open-angle glaucoma to help protect your vision.
Full Timolol Maleate guide →How Each Drug Works
Timolol Maleate
Mechanism of Action Timolol maleate is a beta 1 and beta 2 (non-selective) adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. Timolol Maleate Ophthalmic Gel Forming Solution, when applied topically on the eye, has the action of reducing elevated, as well as normal intraocular pressure, whether or not accompanied by glaucoma. Elevated intraocular pressure is a major risk fa…
Approved Uses (Indications)
Fluoxetine HCl
Fluoxetine is indicated for the treatment of: Acute and maintenance treatment of Major Depressive Disorder [see CLINICAL STUDIES ] . Acute and maintenance treatment of obsessions and compulsions in patients with Obsessive Compulsive Disorder (OCD) [see CLINICAL STUDIES ] . Acute and maintenance treatment of binge-eating and vomiting behaviors in patients with moderate to severe Bulimia Nervosa [see CLINICAL STUDIES ] . Acute treatment of Panic Disorder, with or without agoraphobia [see CLINICAL STUDIES ] . Fluoxetine and Olanzapine in Combination is indicated for the tr…
Timolol Maleate
INDICATIONS AND USAGE Timolol Maleate Ophthalmic Gel Forming Solution is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
Side Effects
Fluoxetine HCl
Timolol Maleate
Cost Comparison
Fluoxetine HCl
$4-$25/month
As a widely available generic, Fluoxetine HCl is very affordable. Patients can often find significant savings using discount cards or by checking prices at different pharmacies.
Timolol Maleate
$50–$150/month
While a generic version of Timolol Maleate eye drops is available, the brand name 'Timolol Maleate' (often referring to specific formulations or strengths) might be more expensive. Patients can often find significant savings by using discount cards or manufacturer coupons, especially if a specific brand formulation is prescribed.
Compare prices for Fluoxetine HCl and Timolol Maleate
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.