Combining Fluoxetine and Metoprolol Succinate is a major interaction and should generally be avoided without close medical supervision.
Fluoxetine can significantly increase the plasma concentrations of metoprolol, a beta-blocker. This interaction can lead to severe bradycardia, hypotension, and potentially heart block, increasing the risk of adverse cardiovascular events.
Mechanism: Fluoxetine is a potent inhibitor of the cytochrome P450 2D6 (CYP2D6) enzyme. Metoprolol is primarily metabolized by CYP2D6, so fluoxetine inhibits its metabolism, leading to reduced clearance and increased systemic exposure of metoprolol.
Fluoxetine vs. Metoprolol Succinate
Compare Fluoxetine and Metoprolol Succinate: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Fluoxetine
Fluoxetine
SSRIs (Selective Serotonin Reuptake Inhibitors)
RxDrug B
Metoprolol Succinate
Metoprolol Succinate
Beta-Blockers
RxQuick Comparison
| Category | Fluoxetine | Metoprolol Succinate |
|---|---|---|
| Drug Class | SSRIs (Selective Serotonin Reuptake Inhibitors) | Beta-Blockers |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $4–$15/month | $4-$25/month |
Fluoxetine Overview
Fluoxetine is a type of antidepressant medication called a selective serotonin reuptake inhibitor (SSRI). It is used to treat conditions like depression, obsessive-compulsive disorder (OCD), bulimia nervosa, and panic disorder by helping to restore the balance of a natural substance called serotonin in the brain.
Full Fluoxetine guide →Metoprolol Succinate Overview
METOPROLOL SUCCINATE (brand name: Metoprolol Succinate) is a Beta-Blockers. 1 INDICATIONS & USAGE Metoprolol succinate extended-release tablets, metoprolol succinate, beta-adrenergic blocker indicated for the treatment of: • Hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and…
Full Metoprolol Succinate guide →How Each Drug Works
Fluoxetine
Although the exact mechanism of fluoxetine is unknown, it is presumed to be linked to its inhibition of CNS neuronal uptake of serotonin.
Approved Uses (Indications)
Fluoxetine
Fluoxetine is a a selective serotonin reuptake inhibitor indicated for: Acute and maintenance treatment of Major Depressive Disorder (MDD) in adult and pediatric patients aged 8 to 18 years Acute and maintenance treatment of Obsessive Compulsive Disorder (OCD) in adults and pediatric patients aged 7 to 17 years Acute and maintenance treatment of Bulimia Nervosa in adult patients Acute treatment of Panic Disorder, with or without agoraphobia, in adult patients 1.1 Major Depressive Disorder Fluoxetine tablets are indicated for the acute and mainten…
Metoprolol Succinate
Metoprolol succinate extended-release tablets, metoprolol succinate, beta-adrenergic blocker indicated for the treatment of:
- Hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.()
- Angina Pectoris. ()
- Heart Failure, to reduce the risk of cardiovascular mortality and heart failure hospitalizations in patients with heart failure() 1.1 Hypertension Metoprolol succinate extended-release tablets is indicated for the treatment of hypertension, to lower blo…
Side Effects
Fluoxetine
Metoprolol Succinate
Cost Comparison
Fluoxetine
$4–$15/month
As a widely available generic, Fluoxetine is very affordable. Patients can often find significant savings by using discount cards like GoodRx or checking prices at different pharmacies.
Metoprolol Succinate
$4-$25/month
Metoprolol Succinate is available as a low-cost generic. Patients can often find significant savings by using discount cards or patient assistance programs.
Compare prices for Fluoxetine and Metoprolol Succinate
Check real-time pharmacy prices before you fill — free, no account needed.
Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.