Combining Fluoxetine and Metoprolol Tartrate is a major interaction and should generally be avoided without close medical supervision.
Fluoxetine is a potent inhibitor of CYP2D6, which is the primary enzyme responsible for the metabolism of metoprolol. This interaction can significantly increase metoprolol plasma concentrations, potentially leading to enhanced beta-blockade effects such as severe bradycardia, hypotension, and heart block.
Mechanism: Fluoxetine inhibits the cytochrome P450 2D6 (CYP2D6) enzyme, thereby reducing the metabolic clearance of metoprolol, a substrate of CYP2D6. This pharmacokinetic interaction leads to elevated systemic exposure to metoprolol.
Fluoxetine vs. Metoprolol Tartrate
Compare Fluoxetine and Metoprolol Tartrate: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Fluoxetine
Fluoxetine
SSRIs (Selective Serotonin Reuptake Inhibitors)
RxDrug B
Metoprolol Tartrate
Metoprolol Tartrate
Beta-Blockers
RxQuick Comparison
| Category | Fluoxetine | Metoprolol Tartrate |
|---|---|---|
| Drug Class | SSRIs (Selective Serotonin Reuptake Inhibitors) | Beta-Blockers |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $4–$15/month | $4–$25/month |
Fluoxetine Overview
Fluoxetine is a type of antidepressant medication called a selective serotonin reuptake inhibitor (SSRI). It is used to treat conditions like depression, obsessive-compulsive disorder (OCD), bulimia nervosa, and panic disorder by helping to restore the balance of a natural substance called serotonin in the brain.
Full Fluoxetine guide →Metoprolol Tartrate Overview
Metoprolol Tartrate is a beta-blocker medication used to treat high blood pressure, chest pain (angina), and to improve outcomes after a heart attack. It works by relaxing blood vessels and slowing the heart rate, which helps to lower blood pressure and reduce the heart's workload.
Full Metoprolol Tartrate guide →How Each Drug Works
Fluoxetine
Although the exact mechanism of fluoxetine is unknown, it is presumed to be linked to its inhibition of CNS neuronal uptake of serotonin.
Approved Uses (Indications)
Fluoxetine
Fluoxetine is a a selective serotonin reuptake inhibitor indicated for: Acute and maintenance treatment of Major Depressive Disorder (MDD) in adult and pediatric patients aged 8 to 18 years Acute and maintenance treatment of Obsessive Compulsive Disorder (OCD) in adults and pediatric patients aged 7 to 17 years Acute and maintenance treatment of Bulimia Nervosa in adult patients Acute treatment of Panic Disorder, with or without agoraphobia, in adult patients 1.1 Major Depressive Disorder Fluoxetine tablets are indicated for the acute and mainten…
Metoprolol Tartrate
Metoprolol tartrate is a beta-adrenergic blocker indicated for the treatment of:
- Hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.
- Angina Pectoris.
- Myocardial Infarction, to reduce the risk of cardiovascular mortality when used in conjunction with intravenous metoprolol therapy in patients with definite or suspected acute myocardial infarction in hemodynamically stable patients.
Hypertension Metoprolol tartrate is in…
Side Effects
Fluoxetine
Metoprolol Tartrate
Cost Comparison
Fluoxetine
$4–$15/month
As a widely available generic, Fluoxetine is very affordable. Patients can often find significant savings by using discount cards like GoodRx or checking prices at different pharmacies.
Metoprolol Tartrate
$4–$25/month
As a widely available generic, Metoprolol Tartrate is typically affordable. Using discount cards like GoodRx can further reduce the cost, often bringing it down to under $10 per month at many pharmacies.
Compare prices for Fluoxetine and Metoprolol Tartrate
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.