Combining Fluoxetine and Nebivolol is a major interaction and should generally be avoided without close medical supervision.
The co-administration of nebivolol and fluoxetine can lead to significantly increased plasma concentrations of nebivolol. This interaction can result in enhanced beta-adrenergic blockade, potentially causing severe bradycardia, hypotension, or heart block.
Mechanism: Fluoxetine is a potent inhibitor of the cytochrome P450 2D6 (CYP2D6) enzyme. Nebivolol is metabolized by CYP2D6, and its metabolism is inhibited by fluoxetine, leading to reduced clearance and elevated systemic exposure of nebivolol.
Fluoxetine vs. Nebivolol
Compare Fluoxetine and Nebivolol: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Fluoxetine
Fluoxetine
SSRIs (Selective Serotonin Reuptake Inhibitors)
RxDrug B
Nebivolol
Nebivolol
Beta-Blockers
RxQuick Comparison
| Category | Fluoxetine | Nebivolol |
|---|---|---|
| Drug Class | SSRIs (Selective Serotonin Reuptake Inhibitors) | Beta-Blockers |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $4–$15/month | $200–$500/month |
Fluoxetine Overview
Fluoxetine is a type of antidepressant medication called a selective serotonin reuptake inhibitor (SSRI). It is used to treat conditions like depression, obsessive-compulsive disorder (OCD), bulimia nervosa, and panic disorder by helping to restore the balance of a natural substance called serotonin in the brain.
Full Fluoxetine guide →Nebivolol Overview
Nebivolol is a beta-blocker medication used to treat high blood pressure (hypertension). By helping to relax blood vessels and slow the heart rate, it lowers blood pressure, which in turn reduces the risk of serious heart problems like strokes and heart attacks.
Full Nebivolol guide →How Each Drug Works
Fluoxetine
Although the exact mechanism of fluoxetine is unknown, it is presumed to be linked to its inhibition of CNS neuronal uptake of serotonin.
Nebivolol
The mechanism of action of the antihypertensive response of nebivolol has not been definitively established. Possible factors that may be involved include: decreased heart rate, decreased myocardial contractility, diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers, suppression of renin activity and vasodilation and decreased peripheral vascular resistance.
Approved Uses (Indications)
Fluoxetine
Fluoxetine is a a selective serotonin reuptake inhibitor indicated for: Acute and maintenance treatment of Major Depressive Disorder (MDD) in adult and pediatric patients aged 8 to 18 years Acute and maintenance treatment of Obsessive Compulsive Disorder (OCD) in adults and pediatric patients aged 7 to 17 years Acute and maintenance treatment of Bulimia Nervosa in adult patients Acute treatment of Panic Disorder, with or without agoraphobia, in adult patients 1.1 Major Depressive Disorder Fluoxetine tablets are indicated for the acute and mainten…
Nebivolol
Nebivolol Tablets are a beta-adrenergic blocking agent indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. 1.1 Hypertension Nebivolol tablets are indicated for the treatment of hypertension, to lower blood pressure [see Clinical Studies ] . Nebivolol tablets may be used alone or in combination with other antihypertensive agents [see Drug Interactions ] . Lowering blood pressure reduces the risk of fata…
Side Effects
Fluoxetine
Nebivolol
Cost Comparison
Fluoxetine
$4–$15/month
As a widely available generic, Fluoxetine is very affordable. Patients can often find significant savings by using discount cards like GoodRx or checking prices at different pharmacies.
Nebivolol
$200–$500/month
Since Nebivolol does not have a generic version, look for manufacturer coupons or patient assistance programs to significantly reduce the cost. Discount cards may also offer some savings.
Compare prices for Fluoxetine and Nebivolol
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.