Combining Fluoxetine and Propranolol Hydrochloride is a major interaction and should generally be avoided without close medical supervision.
Fluoxetine, a potent CYP2D6 inhibitor, can significantly increase plasma concentrations of propranolol, a beta-blocker primarily metabolized by CYP2D6. This interaction can lead to profound bradycardia, hypotension, and other symptoms of beta-blockade.
Mechanism: Fluoxetine inhibits the cytochrome P450 2D6 (CYP2D6) enzyme, which is a primary metabolic pathway for propranolol. This pharmacokinetic interaction reduces propranolol clearance, leading to elevated systemic exposure.
Fluoxetine vs. Propranolol Hydrochloride
Compare Fluoxetine and Propranolol Hydrochloride: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Fluoxetine
Fluoxetine
SSRIs (Selective Serotonin Reuptake Inhibitors)
RxDrug B
Propranolol Hydrochloride
propranolol hydrochloride
Beta-Blockers
RxQuick Comparison
| Category | Fluoxetine | Propranolol Hydrochloride |
|---|---|---|
| Drug Class | SSRIs (Selective Serotonin Reuptake Inhibitors) | Beta-Blockers |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $4–$15/month | $30-$100/month |
Fluoxetine Overview
Fluoxetine is a type of antidepressant medication called a selective serotonin reuptake inhibitor (SSRI). It is used to treat conditions like depression, obsessive-compulsive disorder (OCD), bulimia nervosa, and panic disorder by helping to restore the balance of a natural substance called serotonin in the brain.
Full Fluoxetine guide →Propranolol Hydrochloride Overview
Propranolol hydrochloride is a medication that helps manage conditions like high blood pressure, chest pain (angina), and prevents migraine headaches. It works by affecting certain signals in the body, which helps to slow the heart rate and relax blood vessels, making it easier for the heart to pump blood.
Full Propranolol Hydrochloride guide →How Each Drug Works
Fluoxetine
Although the exact mechanism of fluoxetine is unknown, it is presumed to be linked to its inhibition of CNS neuronal uptake of serotonin.
Propranolol Hydrochloride
Mechanism of Action The mechanism of the antihypertensive effect of propranolol has not been established. Among the factors that may be involved in contributing to the antihypertensive action include: decreased cardiac output, inhibition of renin release by the kidneys, and diminution of tonic sympathetic nerve outflow from vasomotor centers in the brain. Although total peripheral resistance may increase initially, it readjusts to or below the pretreatment level with chronic use of p…
Approved Uses (Indications)
Fluoxetine
Fluoxetine is a a selective serotonin reuptake inhibitor indicated for: Acute and maintenance treatment of Major Depressive Disorder (MDD) in adult and pediatric patients aged 8 to 18 years Acute and maintenance treatment of Obsessive Compulsive Disorder (OCD) in adults and pediatric patients aged 7 to 17 years Acute and maintenance treatment of Bulimia Nervosa in adult patients Acute treatment of Panic Disorder, with or without agoraphobia, in adult patients 1.1 Major Depressive Disorder Fluoxetine tablets are indicated for the acute and mainten…
Propranolol Hydrochloride
INDICATIONS AND USAGE Hypertension Propranolol Hydrochloride Extended-Release Capsules, USP, are indicated in the management of hypertension. They may be used alone or used in combination with other antihypertensive agents, particularly a thiazide diuretic. Propranolol Hydrochloride Extended-Release Capsules, USP, are not indicated in the management of hypertensive emergencies. Angina Pectoris Due to Coronary Atherosclerosis Propranolol Hydrochloride Extended-Release Capsules, USP, are indicated to decrease angina frequency and increase exercise tolerance in patients with angina pectoris. Migr…
Side Effects
Fluoxetine
Propranolol Hydrochloride
Cost Comparison
Fluoxetine
$4–$15/month
As a widely available generic, Fluoxetine is very affordable. Patients can often find significant savings by using discount cards like GoodRx or checking prices at different pharmacies.
Propranolol Hydrochloride
$30-$100/month
Despite the drug being listed as 'brand' in the prompt, Propranolol Hydrochloride is widely available as a generic. Look for generic versions to significantly reduce costs, and consider using discount cards like GoodRx.
Compare prices for Fluoxetine and Propranolol Hydrochloride
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.