Combining Fluoxetine and Timolol Maleate is a major interaction and should generally be avoided without close medical supervision.
The combination of timolol and fluoxetine can lead to significantly increased plasma concentrations of timolol, potentially causing severe bradycardia, hypotension, and heart block. This interaction is particularly concerning given timolol's non-selective beta-blocking effects and systemic absorption even with ophthalmic administration.
Mechanism: Fluoxetine is a potent inhibitor of the cytochrome P450 2D6 (CYP2D6) enzyme. Timolol is primarily metabolized by CYP2D6, so fluoxetine inhibits its metabolism, leading to reduced clearance and increased systemic exposure to timolol.
Fluoxetine vs. Timolol Maleate
Compare Fluoxetine and Timolol Maleate: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Fluoxetine
Fluoxetine
SSRIs (Selective Serotonin Reuptake Inhibitors)
RxDrug B
Timolol Maleate
Timolol Maleate
Beta-Blockers
RxQuick Comparison
| Category | Fluoxetine | Timolol Maleate |
|---|---|---|
| Drug Class | SSRIs (Selective Serotonin Reuptake Inhibitors) | Beta-Blockers |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $4–$15/month | $50–$150/month |
Fluoxetine Overview
Fluoxetine is a type of antidepressant medication called a selective serotonin reuptake inhibitor (SSRI). It is used to treat conditions like depression, obsessive-compulsive disorder (OCD), bulimia nervosa, and panic disorder by helping to restore the balance of a natural substance called serotonin in the brain.
Full Fluoxetine guide →Timolol Maleate Overview
Timolol Maleate is an eye drop medication used to treat high pressure inside the eye. It works by helping to reduce the amount of fluid your eye produces, which in turn lowers the pressure. This medication is primarily prescribed for conditions like ocular hypertension and open-angle glaucoma to help protect your vision.
Full Timolol Maleate guide →How Each Drug Works
Fluoxetine
Although the exact mechanism of fluoxetine is unknown, it is presumed to be linked to its inhibition of CNS neuronal uptake of serotonin.
Timolol Maleate
Mechanism of Action Timolol maleate is a beta 1 and beta 2 (non-selective) adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. Timolol Maleate Ophthalmic Gel Forming Solution, when applied topically on the eye, has the action of reducing elevated, as well as normal intraocular pressure, whether or not accompanied by glaucoma. Elevated intraocular pressure is a major risk fa…
Approved Uses (Indications)
Fluoxetine
Fluoxetine is a a selective serotonin reuptake inhibitor indicated for: Acute and maintenance treatment of Major Depressive Disorder (MDD) in adult and pediatric patients aged 8 to 18 years Acute and maintenance treatment of Obsessive Compulsive Disorder (OCD) in adults and pediatric patients aged 7 to 17 years Acute and maintenance treatment of Bulimia Nervosa in adult patients Acute treatment of Panic Disorder, with or without agoraphobia, in adult patients 1.1 Major Depressive Disorder Fluoxetine tablets are indicated for the acute and mainten…
Timolol Maleate
INDICATIONS AND USAGE Timolol Maleate Ophthalmic Gel Forming Solution is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
Side Effects
Fluoxetine
Timolol Maleate
Cost Comparison
Fluoxetine
$4–$15/month
As a widely available generic, Fluoxetine is very affordable. Patients can often find significant savings by using discount cards like GoodRx or checking prices at different pharmacies.
Timolol Maleate
$50–$150/month
While a generic version of Timolol Maleate eye drops is available, the brand name 'Timolol Maleate' (often referring to specific formulations or strengths) might be more expensive. Patients can often find significant savings by using discount cards or manufacturer coupons, especially if a specific brand formulation is prescribed.
Compare prices for Fluoxetine and Timolol Maleate
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.