Fluvoxamine Maleate vs. Metoprolol Tartrate
Compare Fluvoxamine Maleate and Metoprolol Tartrate: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Fluvoxamine Maleate
Fluvoxamine Maleate
SSRIs (Selective Serotonin Reuptake Inhibitors)
RxDrug B
Metoprolol Tartrate
Metoprolol Tartrate
Beta-Blockers
RxQuick Comparison
| Category | Fluvoxamine Maleate | Metoprolol Tartrate |
|---|---|---|
| Drug Class | SSRIs (Selective Serotonin Reuptake Inhibitors) | Beta-Blockers |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $15–$50/month | $4–$25/month |
Fluvoxamine Maleate Overview
Fluvoxamine Maleate is a type of antidepressant medication called a Selective Serotonin Reuptake Inhibitor (SSRI). It works by helping to balance certain natural substances in the brain, and it is primarily used to treat Obsessive Compulsive Disorder (OCD) by reducing repetitive thoughts and behaviors.
Full Fluvoxamine Maleate guide →Metoprolol Tartrate Overview
Metoprolol Tartrate is a beta-blocker medication used to treat high blood pressure, chest pain (angina), and to improve outcomes after a heart attack. It works by relaxing blood vessels and slowing the heart rate, which helps to lower blood pressure and reduce the heart's workload.
Full Metoprolol Tartrate guide →Approved Uses (Indications)
Fluvoxamine Maleate
Fluvoxamine maleate extended-release capsules are selective serotonin reuptake inhibitor (SSRI) indicated for the treatment of obsessive compulsive disorder (OCD) . Efficacy was demonstrated in: One 12-week study with fluvoxamine maleate extended-release capsules in adults . Two 10-week studies with immediate-release (IR) fluvoxamine tablets in adults and one 10-week study with IR fluvoxamine tablets in children and adolescents . One maintenance study with IR fluvoxamine tablets .
Obsessive Compulsive Disorder Fluvoxamine malea…
Metoprolol Tartrate
Metoprolol tartrate is a beta-adrenergic blocker indicated for the treatment of:
- Hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.
- Angina Pectoris.
- Myocardial Infarction, to reduce the risk of cardiovascular mortality when used in conjunction with intravenous metoprolol therapy in patients with definite or suspected acute myocardial infarction in hemodynamically stable patients.
Hypertension Metoprolol tartrate is in…
Side Effects
Fluvoxamine Maleate
Metoprolol Tartrate
Cost Comparison
Fluvoxamine Maleate
$15–$50/month
Fluvoxamine Maleate is available as a generic, which significantly lowers its cost. Patients can typically find good discounts using pharmacy savings cards or manufacturer coupons.
Metoprolol Tartrate
$4–$25/month
As a widely available generic, Metoprolol Tartrate is typically affordable. Using discount cards like GoodRx can further reduce the cost, often bringing it down to under $10 per month at many pharmacies.
Drug Interaction: Moderate
Coadministration of fluvoxamine with metoprolol may increase metoprolol plasma concentrations, leading to enhanced beta-blockade effects such as bradycardia, hypotension, and heart block. While fluvoxamine is primarily a CYP1A2 and CYP2C19 inhibitor, metoprolol is mainly metabolized by CYP2D6, suggesting a lower risk of significant pharmacokinetic interaction than with potent CYP2D6 inhibitors. However, both drugs can independently cause bradycardia, and additive pharmacodynamic effects are possible.
Mechanism: Metoprolol is primarily metabolized by CYP2D6. Fluvoxamine is a potent inhibitor of CYP1A2 and CYP2C19, and a moderate inhibitor of CYP2D6. Inhibition of metoprolol's metabolism by fluvoxamine's CYP2D6 inhibitory activity, even if moderate, can increase metoprolol plasma levels. Additionally, both drugs can cause bradycardia, leading to potential additive pharmacodynamic effects.
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Medical Disclaimer
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