Combining Fluvoxamine Maleate and Propranolol Hydrochloride is a major interaction and should generally be avoided without close medical supervision.
Coadministration of fluvoxamine with propranolol can significantly increase propranolol plasma concentrations, leading to enhanced beta-blockade effects. This can manifest as severe bradycardia, hypotension, and potentially heart block, increasing the risk of adverse cardiovascular events.
Mechanism: Fluvoxamine is a potent inhibitor of CYP1A2 and CYP2C19, both of which are involved in the metabolism of propranolol. Inhibition of these enzymes reduces propranolol clearance, leading to elevated systemic exposure.
Fluvoxamine Maleate vs. Propranolol Hydrochloride
Compare Fluvoxamine Maleate and Propranolol Hydrochloride: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Fluvoxamine Maleate
Fluvoxamine Maleate
SSRIs (Selective Serotonin Reuptake Inhibitors)
RxDrug B
Propranolol Hydrochloride
propranolol hydrochloride
Beta-Blockers
RxQuick Comparison
| Category | Fluvoxamine Maleate | Propranolol Hydrochloride |
|---|---|---|
| Drug Class | SSRIs (Selective Serotonin Reuptake Inhibitors) | Beta-Blockers |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $15–$50/month | $30-$100/month |
Fluvoxamine Maleate Overview
Fluvoxamine Maleate is a type of antidepressant medication called a Selective Serotonin Reuptake Inhibitor (SSRI). It works by helping to balance certain natural substances in the brain, and it is primarily used to treat Obsessive Compulsive Disorder (OCD) by reducing repetitive thoughts and behaviors.
Full Fluvoxamine Maleate guide →Propranolol Hydrochloride Overview
Propranolol hydrochloride is a medication that helps manage conditions like high blood pressure, chest pain (angina), and prevents migraine headaches. It works by affecting certain signals in the body, which helps to slow the heart rate and relax blood vessels, making it easier for the heart to pump blood.
Full Propranolol Hydrochloride guide →How Each Drug Works
Propranolol Hydrochloride
Mechanism of Action The mechanism of the antihypertensive effect of propranolol has not been established. Among the factors that may be involved in contributing to the antihypertensive action include: decreased cardiac output, inhibition of renin release by the kidneys, and diminution of tonic sympathetic nerve outflow from vasomotor centers in the brain. Although total peripheral resistance may increase initially, it readjusts to or below the pretreatment level with chronic use of p…
Approved Uses (Indications)
Fluvoxamine Maleate
Fluvoxamine maleate extended-release capsules are selective serotonin reuptake inhibitor (SSRI) indicated for the treatment of obsessive compulsive disorder (OCD) . Efficacy was demonstrated in: One 12-week study with fluvoxamine maleate extended-release capsules in adults . Two 10-week studies with immediate-release (IR) fluvoxamine tablets in adults and one 10-week study with IR fluvoxamine tablets in children and adolescents . One maintenance study with IR fluvoxamine tablets .
Obsessive Compulsive Disorder Fluvoxamine malea…
Propranolol Hydrochloride
INDICATIONS AND USAGE Hypertension Propranolol Hydrochloride Extended-Release Capsules, USP, are indicated in the management of hypertension. They may be used alone or used in combination with other antihypertensive agents, particularly a thiazide diuretic. Propranolol Hydrochloride Extended-Release Capsules, USP, are not indicated in the management of hypertensive emergencies. Angina Pectoris Due to Coronary Atherosclerosis Propranolol Hydrochloride Extended-Release Capsules, USP, are indicated to decrease angina frequency and increase exercise tolerance in patients with angina pectoris. Migr…
Side Effects
Fluvoxamine Maleate
Propranolol Hydrochloride
Cost Comparison
Fluvoxamine Maleate
$15–$50/month
Fluvoxamine Maleate is available as a generic, which significantly lowers its cost. Patients can typically find good discounts using pharmacy savings cards or manufacturer coupons.
Propranolol Hydrochloride
$30-$100/month
Despite the drug being listed as 'brand' in the prompt, Propranolol Hydrochloride is widely available as a generic. Look for generic versions to significantly reduce costs, and consider using discount cards like GoodRx.
Compare prices for Fluvoxamine Maleate and Propranolol Hydrochloride
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.