Combining Hydromorphone Hydrochloride and Orphenadrine Citrate is a major interaction and should generally be avoided without close medical supervision.
Patients may experience profound sedation, respiratory depression, hypotension, coma, and even death. Impaired psychomotor function, dizziness, and confusion are also common. The risk of these adverse effects is significantly increased when both drugs are used concurrently.
Mechanism: Hydromorphone is an opioid analgesic that primarily acts on mu-opioid receptors in the central nervous system (CNS), leading to dose-dependent CNS depression, including respiratory depression and sedation. Orphenadrine is an anticholinergic agent with muscle relaxant properties that also exerts significant CNS depressant effects. The co-administration of these agents results in an additive depressant effect on the CNS.
Hydromorphone Hydrochloride vs. Orphenadrine Citrate
Compare Hydromorphone Hydrochloride and Orphenadrine Citrate: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Hydromorphone Hydrochloride
Hydromorphone Hydrochloride
Opioid Analgesics
RxDrug B
Orphenadrine Citrate
Orphenadrine Citrate
Skeletal Muscle Relaxants
RxQuick Comparison
| Category | Hydromorphone Hydrochloride | Orphenadrine Citrate |
|---|---|---|
| Drug Class | Opioid Analgesics | Skeletal Muscle Relaxants |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $200–$500/month | $150–$400/month |
Hydromorphone Hydrochloride Overview
HYDROMORPHONE HYDROCHLORIDE (brand name: Hydromorphone Hydrochloride) is a Opioid Analgesics. INDICATIONS AND USAGE Hydromorphone Hydrochloride Injection is indicated for the relief of moderate to severe pain such as that due to: surgery, cancer, trauma (soft tissue and bone), biliary colic, myocardial infarction, burns, renal colic.
Full Hydromorphone Hydrochloride guide →Orphenadrine Citrate Overview
Orphenadrine Citrate is a prescription medication used to help relieve muscle discomfort and pain. It works by relaxing muscles and reducing stiffness, often prescribed alongside rest and physical therapy for acute muscle conditions.
Full Orphenadrine Citrate guide →Approved Uses (Indications)
Hydromorphone Hydrochloride
INDICATIONS AND USAGE Hydromorphone Hydrochloride Injection is indicated for the relief of moderate to severe pain such as that due to: surgery, cancer, trauma (soft tissue and bone), biliary colic, myocardial infarction, burns, renal colic.
Orphenadrine Citrate
INDICATIONS AND USAGE Orphenadrine citrate extended-release tablets are indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions.
Side Effects
Hydromorphone Hydrochloride
Orphenadrine Citrate
Cost Comparison
Hydromorphone Hydrochloride
$200–$500/month
As a brand-only medication, costs without insurance can be high. Discuss patient assistance programs with your doctor or pharmacist for potential savings.
Orphenadrine Citrate
$150–$400/month
Since Orphenadrine Citrate is only available as a brand-name drug, look for manufacturer coupons or patient assistance programs to help reduce the cost. Discount cards may also offer some savings, but manufacturer programs are often more substantial for brand medications.
Compare prices for Hydromorphone Hydrochloride and Orphenadrine Citrate
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.