Combining Hydromorphone Hydrochloride and Temazepam is a major interaction and should generally be avoided without close medical supervision.
The combination significantly increases the risk of severe respiratory depression, profound sedation, coma, and death. Patients may experience decreased level of consciousness, hypoventilation, pinpoint pupils, and hypotension.
Mechanism: Both hydromorphone (an opioid agonist) and temazepam (a benzodiazepine) are central nervous system (CNS) depressants. Their co-administration leads to an additive depressant effect on the CNS, primarily by enhancing GABAergic neurotransmission (benzodiazepines) and inhibiting neuronal activity (opioids), resulting in profound respiratory depression and sedation.
Hydromorphone Hydrochloride vs. Temazepam
Compare Hydromorphone Hydrochloride and Temazepam: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Hydromorphone Hydrochloride
Hydromorphone Hydrochloride
Opioid Analgesics
RxDrug B
Temazepam
temazepam
Benzodiazepines
RxQuick Comparison
| Category | Hydromorphone Hydrochloride | Temazepam |
|---|---|---|
| Drug Class | Opioid Analgesics | Benzodiazepines |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $200–$500/month | $20–$70/month |
Hydromorphone Hydrochloride Overview
HYDROMORPHONE HYDROCHLORIDE (brand name: Hydromorphone Hydrochloride) is a Opioid Analgesics. INDICATIONS AND USAGE Hydromorphone Hydrochloride Injection is indicated for the relief of moderate to severe pain such as that due to: surgery, cancer, trauma (soft tissue and bone), biliary colic, myocardial infarction, burns, renal colic.
Full Hydromorphone Hydrochloride guide →Temazepam Overview
TEMAZEPAM (brand name: temazepam) is a Benzodiazepines. INDICATIONS & USAGE Temazepam Capsules, USP are indicated for the short-term treatment of insomnia (generally 7 to 10 days). For patients with short-term insomnia, instructions in the prescription should indicate that Temazepam Capsules should be used for short periods of time (7 to 10 days). The…
Full Temazepam guide →Approved Uses (Indications)
Hydromorphone Hydrochloride
INDICATIONS AND USAGE Hydromorphone Hydrochloride Injection is indicated for the relief of moderate to severe pain such as that due to: surgery, cancer, trauma (soft tissue and bone), biliary colic, myocardial infarction, burns, renal colic.
Temazepam
INDICATIONS & USAGE Temazepam Capsules, USP are indicated for the short-term treatment of insomnia (generally 7 to 10 days). For patients with short-term insomnia, instructions in the prescription should indicate that Temazepam Capsules should be used for short periods of time (7 to 10 days). The clinical trials performed in support of efficacy were 2 weeks in duration with the final formal assessment of sleep latency performed at the end of treatment.
Side Effects
Hydromorphone Hydrochloride
Temazepam
Cost Comparison
Hydromorphone Hydrochloride
$200–$500/month
As a brand-only medication, costs without insurance can be high. Discuss patient assistance programs with your doctor or pharmacist for potential savings.
Temazepam
$20–$70/month
Although there is no generic available, discount cards like GoodRx can often help reduce the cost of Temazepam significantly. Comparing prices at different pharmacies is also recommended.
Compare prices for Hydromorphone Hydrochloride and Temazepam
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.