Hydromorphone Hydrochloride and Triazolam must not be used together. This combination is classified as CONTRAINDICATED.
The combination significantly increases the risk of severe adverse events including profound sedation, respiratory depression, coma, and death. Patients may experience extreme drowsiness, confusion, dizziness, slowed or stopped breathing, and unresponsiveness.
Mechanism: Both hydromorphone (an opioid agonist) and triazolam (a benzodiazepine) are central nervous system (CNS) depressants. Their co-administration leads to additive pharmacodynamic effects, primarily by enhancing GABAergic neurotransmission (benzodiazepine) and agonizing mu-opioid receptors (opioid), resulting in profound CNS and respiratory depression.
Hydromorphone Hydrochloride vs. Triazolam
Compare Hydromorphone Hydrochloride and Triazolam: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Hydromorphone Hydrochloride
Hydromorphone Hydrochloride
Opioid Analgesics
RxDrug B
Triazolam
Triazolam
Benzodiazepines
RxQuick Comparison
| Category | Hydromorphone Hydrochloride | Triazolam |
|---|---|---|
| Drug Class | Opioid Analgesics | Benzodiazepines |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $200–$500/month | $200–$500/month |
Hydromorphone Hydrochloride Overview
HYDROMORPHONE HYDROCHLORIDE (brand name: Hydromorphone Hydrochloride) is a Opioid Analgesics. INDICATIONS AND USAGE Hydromorphone Hydrochloride Injection is indicated for the relief of moderate to severe pain such as that due to: surgery, cancer, trauma (soft tissue and bone), biliary colic, myocardial infarction, burns, renal colic.
Full Hydromorphone Hydrochloride guide →Triazolam Overview
Triazolam is a benzodiazepine medication prescribed for the short-term treatment of insomnia in adults. It works by enhancing the activity of a natural calming chemical in your brain, which helps you fall asleep. This medication is typically used for brief periods, usually 7 to 10 days.
Full Triazolam guide →How Each Drug Works
Triazolam
Triazolam is a benzodiazepine. Triazolam exerts its effect for the short-term treatment of insomnia through binding to the benzodiazepine site of the gamma-aminobutyric acid-A (GABA A ) receptors in the brain and enhances GABA-mediated synaptic inhibition.
Approved Uses (Indications)
Hydromorphone Hydrochloride
INDICATIONS AND USAGE Hydromorphone Hydrochloride Injection is indicated for the relief of moderate to severe pain such as that due to: surgery, cancer, trauma (soft tissue and bone), biliary colic, myocardial infarction, burns, renal colic.
Triazolam
Triazolam is indicated for the short-term treatment of insomnia (generally 7 to 10 days) in adults. Triazolam is a benzodiazepine indicated for the short-term treatment of insomnia (generally 7 to 10 days) in adults.
Side Effects
Hydromorphone Hydrochloride
Triazolam
Cost Comparison
Hydromorphone Hydrochloride
$200–$500/month
As a brand-only medication, costs without insurance can be high. Discuss patient assistance programs with your doctor or pharmacist for potential savings.
Triazolam
$200–$500/month
Since Triazolam is a brand-only medication, look for manufacturer coupons or patient assistance programs to help reduce the cost. Discount cards may also offer some savings.
Compare prices for Hydromorphone Hydrochloride and Triazolam
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Medical Disclaimer
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