Combining Ibuprofen and Ticagrelor is a major interaction and should generally be avoided without close medical supervision.
Combining ibuprofen with ticagrelor significantly increases your risk of bleeding, especially from the stomach or intestines. This combination should generally be avoided due to the heightened bleeding potential.
Mechanism: Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis and impairing platelet aggregation. Ticagrelor is an antiplatelet agent that directly inhibits the P2Y12 receptor, preventing ADP-mediated platelet activation and aggregation. The concurrent use of these agents leads to additive antiplatelet effects and increased gastrointestinal mucosal damage, profoundly elevating bleeding risk.
Ibuprofen vs. Ticagrelor
Compare Ibuprofen and Ticagrelor: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Ibuprofen
good neighbor pharmacy ibuprofen
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Ticagrelor
Ticagrelor
Antiplatelet Agents
RxQuick Comparison
| Category | Ibuprofen | Ticagrelor |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | Antiplatelet Agents |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $4-$15/month | $400–$700/month |
Ibuprofen Overview
IBUPROFEN (brand name: good neighbor pharmacy ibuprofen) is a NSAIDs. Uses • temporarily relieves minor aches and pains due to: • headache • muscular aches • minor pain of arthritis • toothache • backache • the common cold • menstrual cramps • temporarily reduces fever
Full Ibuprofen guide →Ticagrelor Overview
Ticagrelor is an anti-platelet medication that helps prevent blood clots. It works by making your platelets (tiny blood cells involved in clotting) less sticky, reducing the risk of serious heart problems like heart attacks and strokes, especially in people with acute coronary syndrome or a history of heart disease.
Full Ticagrelor guide →How Each Drug Works
Ticagrelor
Ticagrelor and its major metabolite reversibly interact with the platelet P2Y 12 ADP-receptor to prevent signal transduction and platelet activation. Ticagrelor and its active metabolite are approximately equipotent.
Approved Uses (Indications)
Ibuprofen
Uses
- temporarily relieves minor aches and pains due to:
- headache
- muscular aches
- minor pain of arthritis
- toothache
- backache
- the common cold
- menstrual cramps
- temporarily reduces fever
Ticagrelor
Ticagrelor tablets are a P2Y 12 platelet inhibitor indicated
- to reduce the risk of cardiovascular (CV) death, myocardial infarction (MI), and stroke in patients with acute coronary syndrome (ACS) or a history of MI. For at least the first 12 months following ACS, it is superior to clopidogrel. Ticagrelor tablets also reduce the risk of stent thrombosis in patients who have been stented for treatment of ACS.
- to reduce the risk of a first MI or stroke in patients with coronary artery disease (CAD) at high risk for such events. While use is not limited to this …
Side Effects
Ticagrelor
Cost Comparison
Ibuprofen
$4-$15/month
Ibuprofen is widely available as an inexpensive generic, even without insurance. Discount cards can further reduce the cost at many pharmacies.
Ticagrelor
$400–$700/month
As a brand-name medication, Ticagrelor can be expensive. Patients should look for manufacturer patient assistance programs or discount cards like GoodRx to help reduce the cost.
Compare prices for Ibuprofen and Ticagrelor
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.