Combining Indomethacin and Rivaroxaban is a major interaction and should generally be avoided without close medical supervision.
Combining indomethacin with rivaroxaban significantly increases your risk of bleeding, especially in the stomach and intestines. This combination should generally be avoided.
Mechanism: Indomethacin, a nonsteroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase enzymes, leading to reduced prostaglandin synthesis. This results in impaired platelet aggregation and can cause direct irritation and damage to the gastrointestinal mucosa. Rivaroxaban is a direct oral anticoagulant (DOAC) that directly inhibits Factor Xa, preventing thrombin generation and clot formation. The concurrent use of these agents leads to an additive antiplatelet and anticoagulant effect, significantly increasing the risk of bleeding.
Indomethacin vs. Rivaroxaban
Compare Indomethacin and Rivaroxaban: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Indomethacin
Indomethacin
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Rivaroxaban
rivaroxaban
Anticoagulants
RxQuick Comparison
| Category | Indomethacin | Rivaroxaban |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | Anticoagulants |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $30–$80/month | $400–$600/month |
Indomethacin Overview
INDOMETHACIN (brand name: Indomethacin) is a NSAIDs. INDICATIONS AND USAGE Carefully consider the potential benefits and risks of indomethacin capsules and other treatment options before deciding to use indomethacin. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS ).…
Full Indomethacin guide →Rivaroxaban Overview
RIVAROXABAN (brand name: rivaroxaban) is a Anticoagulants. 1 INDICATIONS & USAGE Rivaroxaban is a factor Xa inhibitor indicated: to reduce the risk of major cardiovascular events in patients with coronary artery disease (CAD) ( 1.7 ) to reduce the risk of major thrombotic vascular events in patients with peripheral artery disease (PAD), including patients…
Full Rivaroxaban guide →How Each Drug Works
Rivaroxaban
Rivaroxaban is a selective inhibitor of FXa. It does not require a cofactor (such as Anti-thrombin III) for activity. Rivaroxaban inhibits free FXa and prothrombinase activity. Rivaroxaban has no direct effect on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin. By inhibiting FXa, rivaroxaban decreases thrombin generation.
Approved Uses (Indications)
Indomethacin
INDICATIONS AND USAGE Carefully consider the potential benefits and risks of indomethacin capsules and other treatment options before deciding to use indomethacin. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS ). Indomethacin Capsule, USP has been found effective in active stages of the following: Moderate to severe rheumatoid arthritis including acute flares of chronic disease. Moderate to severe ankylosing spondylitis. Moderate to severe osteoarthritis. Acute painful shoulder (bursitis and/or tendinitis). Acute gouty …
Rivaroxaban
Rivaroxaban is a factor Xa inhibitor indicated: to reduce the risk of major cardiovascular events in patients with coronary artery disease (CAD) to reduce the risk of major thrombotic vascular events in patients with peripheral artery disease (PAD), including patients after recent lower extremity revascularization due to symptomatic PAD 1.7 Reduction of Risk of Major Cardiovascular Events in Patients with Coronary Artery Disease (CAD) Rivaroxaban tablets, in combination with aspirin, are indicated to reduce the risk of major cardiovascular events (cardiova…
Side Effects
Indomethacin
Rivaroxaban
Cost Comparison
Indomethacin
$30–$80/month
While Indomethacin is available generically, its brand name is also Indomethacin. Using discount cards like GoodRx can often help reduce the cost significantly.
Rivaroxaban
$400–$600/month
As a brand-only medication, Rivaroxaban can be expensive. Check the manufacturer's website for patient assistance programs or coupons, and compare prices at different pharmacies using discount cards.
Compare prices for Indomethacin and Rivaroxaban
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.