Combining Indomethacin and Warfarin is a major interaction and should generally be avoided without close medical supervision.
Combining indomethacin with warfarin significantly increases your risk of serious bleeding, including stomach bleeding. Your doctor will likely avoid this combination or monitor you very closely.
Mechanism: Indomethacin, a non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis. This leads to impaired platelet aggregation and can cause gastric mucosal damage, increasing the risk of gastrointestinal bleeding. Warfarin is an anticoagulant that inhibits vitamin K-dependent clotting factors, leading to a reduced clotting ability. The concurrent use of these drugs results in additive antiplatelet and anticoagulant effects, alongside increased GI mucosal vulnerability.
Indomethacin vs. Warfarin
Compare Indomethacin and Warfarin: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Indomethacin
Indomethacin
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Warfarin
Warfarin Sodium
Anticoagulants
RxQuick Comparison
| Category | Indomethacin | Warfarin |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | Anticoagulants |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $30–$80/month | $10–$30/month |
Indomethacin Overview
INDOMETHACIN (brand name: Indomethacin) is a NSAIDs. INDICATIONS AND USAGE Carefully consider the potential benefits and risks of indomethacin capsules and other treatment options before deciding to use indomethacin. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS ).…
Full Indomethacin guide →Warfarin Overview
Warfarin is a "blood thinner" (anticoagulant) medication that helps prevent harmful blood clots from forming or growing larger in your body. It is prescribed to reduce the risk of serious problems like strokes, heart attacks, and clots in the legs or lungs, especially for people with certain heart conditions or after a heart attack.
Full Warfarin guide →Approved Uses (Indications)
Indomethacin
INDICATIONS AND USAGE Carefully consider the potential benefits and risks of indomethacin capsules and other treatment options before deciding to use indomethacin. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS ). Indomethacin Capsule, USP has been found effective in active stages of the following: Moderate to severe rheumatoid arthritis including acute flares of chronic disease. Moderate to severe ankylosing spondylitis. Moderate to severe osteoarthritis. Acute painful shoulder (bursitis and/or tendinitis). Acute gouty …
Warfarin
Warfarin sodium tablets are indicated for: Prophylaxis and treatment of venous thrombosis and its extension, pulmonary embolism (PE). Prophylaxis and treatment of thromboembolic complications associated with atrial fibrillation (AF) and/or cardiac valve replacement. Reduction in the risk of death, recurrent myocardial infarction (MI), and thromboembolic events such as stroke or systemic embolization after myocardial infarction. Limitations of Use Warfarin sodium tablets have no direct effect on an established thrombus, nor does it reverse ischemic tissue damage. Once a …
Side Effects
Indomethacin
Warfarin
Cost Comparison
Indomethacin
$30–$80/month
While Indomethacin is available generically, its brand name is also Indomethacin. Using discount cards like GoodRx can often help reduce the cost significantly.
Warfarin
$10–$30/month
Warfarin is available as a generic and is generally very affordable. Using discount cards like GoodRx can often reduce the cost further, even without insurance.
Compare prices for Indomethacin and Warfarin
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.