Combining Ketorolac Tromethamine and Ticagrelor is a major interaction and should generally be avoided without close medical supervision.
Combining ketorolac with ticagrelor significantly increases your risk of bleeding, including serious and life-threatening events such as stomach bleeding or stroke.
Mechanism: Ketorolac, a non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase (COX) enzymes, leading to reduced prostaglandin synthesis and impaired platelet aggregation. Ticagrelor is an antiplatelet agent that directly inhibits the P2Y12 ADP receptor on platelets, preventing their activation and aggregation. The concurrent use of these agents results in a synergistic inhibition of platelet function and disruption of the gastrointestinal mucosal barrier, markedly increasing bleeding risk.
Ketorolac Tromethamine vs. Ticagrelor
Compare Ketorolac Tromethamine and Ticagrelor: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Ketorolac Tromethamine
Ketorolac Tromethamine
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Ticagrelor
Ticagrelor
Antiplatelet Agents
RxQuick Comparison
| Category | Ketorolac Tromethamine | Ticagrelor |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | Antiplatelet Agents |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $10–$50/month | $400–$700/month |
Ketorolac Tromethamine Overview
KETOROLAC TROMETHAMINE (brand name: Ketorolac Tromethamine) is a NSAIDs. INDICATIONS AND USAGE Carefully consider the potential benefits and risks of Ketorolac Tromethamine Tablets USP and other treatment options before deciding to use Ketorolac Tromethamine Tablets USP. Use the lowest effective dose for the shortest duration consistent with individual patient treatment…
Full Ketorolac Tromethamine guide →Ticagrelor Overview
Ticagrelor is an anti-platelet medication that helps prevent blood clots. It works by making your platelets (tiny blood cells involved in clotting) less sticky, reducing the risk of serious heart problems like heart attacks and strokes, especially in people with acute coronary syndrome or a history of heart disease.
Full Ticagrelor guide →How Each Drug Works
Ticagrelor
Ticagrelor and its major metabolite reversibly interact with the platelet P2Y 12 ADP-receptor to prevent signal transduction and platelet activation. Ticagrelor and its active metabolite are approximately equipotent.
Approved Uses (Indications)
Ketorolac Tromethamine
INDICATIONS AND USAGE Carefully consider the potential benefits and risks of Ketorolac Tromethamine Tablets USP and other treatment options before deciding to use Ketorolac Tromethamine Tablets USP. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals. Acute Pain in Adult Patients Ketorolac Tromethamine Tablets USP are indicated for the short-term (≤ 5 days) management of moderately severe acute pain that requires analgesia at the opioid level, usually in a postoperative setting. Therapy should always be initiated with IV or IM dosing of ke…
Ticagrelor
Ticagrelor tablets are a P2Y 12 platelet inhibitor indicated
- to reduce the risk of cardiovascular (CV) death, myocardial infarction (MI), and stroke in patients with acute coronary syndrome (ACS) or a history of MI. For at least the first 12 months following ACS, it is superior to clopidogrel. Ticagrelor tablets also reduce the risk of stent thrombosis in patients who have been stented for treatment of ACS.
- to reduce the risk of a first MI or stroke in patients with coronary artery disease (CAD) at high risk for such events. While use is not limited to this …
Side Effects
Ketorolac Tromethamine
Ticagrelor
Cost Comparison
Ketorolac Tromethamine
$10–$50/month
As a widely available generic, Ketorolac Tromethamine is typically inexpensive. Using discount cards like GoodRx can often reduce the cost further to just a few dollars per month.
Ticagrelor
$400–$700/month
As a brand-name medication, Ticagrelor can be expensive. Patients should look for manufacturer patient assistance programs or discount cards like GoodRx to help reduce the cost.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.