Lorazepam and Morphine must not be used together. This combination is classified as CONTRAINDICATED.
The combination significantly increases the risk of severe respiratory depression, profound sedation, coma, and death. Patients may experience decreased level of consciousness, hypoventilation, hypoxia, and hypotension. Psychomotor impairment and an increased risk of falls are also common.
Mechanism: Morphine, an opioid agonist, primarily acts on mu-opioid receptors in the central nervous system (CNS) to produce analgesia and respiratory depression. Lorazepam, a benzodiazepine, enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) at GABA-A receptors. The co-administration of these two CNS depressants leads to additive or synergistic depression of the CNS, particularly affecting respiratory drive.
Lorazepam vs. Morphine
Compare Lorazepam and Morphine: mechanism of action, indications, side effects, cost, and which may be right for you.
Quick Comparison
| Category | Lorazepam | Morphine |
|---|---|---|
| Drug Class | Benzodiazepines | Opioid Analgesics |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $10–$50/month | $200–$600/month |
Lorazepam Overview
Lorazepam is a prescription medication used to help manage anxiety disorders and provide short-term relief from anxiety symptoms. It works by calming the brain and nerves, which can help reduce feelings of worry and tension.
Full Lorazepam guide →Morphine Overview
MORPHINE (brand name: Opium Tincture Deodorized) is a Opioid Analgesics. INDICATIONS AND USAGE Opium tincture is useful for the treatment of diarrhea.
Full Morphine guide →Approved Uses (Indications)
Lorazepam
INDICATIONS AND USAGE Lorazepam tablets are indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic. The effectiveness of lorazepam tablets in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The physician should periodically reassess the usefulness of the drug for the individual patient.
Morphine
INDICATIONS AND USAGE Opium tincture is useful for the treatment of diarrhea.
Side Effects
Lorazepam
Morphine
Cost Comparison
Lorazepam
$10–$50/month
Lorazepam is a widely available generic, making it relatively inexpensive. Patients can often find significant savings by using discount cards or comparing prices at different pharmacies.
Morphine
$200–$600/month
As there is no generic available, patients should look for manufacturer patient assistance programs or discount cards to help reduce the cost of Opium Tincture Deodorized.
Compare prices for Lorazepam and Morphine
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Medical Disclaimer
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