Combining Lorazepam and Tapentadol Hydrochloride is a major interaction and should generally be avoided without close medical supervision.
Concomitant use significantly increases the risk of severe respiratory depression, profound sedation, coma, and death. Patients may exhibit decreased level of consciousness, bradycardia, hypotension, and hypoxemia. This interaction can also impair psychomotor function, increasing the risk of falls and accidents.
Mechanism: Both tapentadol (an opioid analgesic with norepinephrine reuptake inhibition) and lorazepam (a benzodiazepine) are central nervous system (CNS) depressants. Tapentadol's opioid activity primarily agonizes mu-opioid receptors, while lorazepam enhances the effect of the inhibitory neurotransmitter GABA at GABA-A receptors. The additive CNS depressant effects of these two drug classes lead to profound respiratory depression, sedation, and hypotension.
Lorazepam vs. Tapentadol Hydrochloride
Compare Lorazepam and Tapentadol Hydrochloride: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Lorazepam
Lorazepam
Benzodiazepines
RxDrug B
Tapentadol Hydrochloride
Tapentadol Hydrochloride
Opioid Analgesics
RxQuick Comparison
| Category | Lorazepam | Tapentadol Hydrochloride |
|---|---|---|
| Drug Class | Benzodiazepines | Opioid Analgesics |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $10–$50/month | $300–$800/month |
Lorazepam Overview
Lorazepam is a prescription medication used to help manage anxiety disorders and provide short-term relief from anxiety symptoms. It works by calming the brain and nerves, which can help reduce feelings of worry and tension.
Full Lorazepam guide →Tapentadol Hydrochloride Overview
TAPENTADOL HYDROCHLORIDE (brand name: Tapentadol Hydrochloride) is a Opioid Analgesics. 1 INDICATIONS AND USAGE Tapentadol tablets are indicated for the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate in adults. Limitations of Use Because of the risks of addiction, abuse, misuse, overdose, and death, which can…
Full Tapentadol Hydrochloride guide →How Each Drug Works
Tapentadol Hydrochloride
Tapentadol is a centrally-acting synthetic analgesic. The exact mechanism of action is unknown. Although the clinical relevance is unclear, preclinical studies have shown that tapentadol is a mu-opioid receptor (MOR) agonist and a norepinephrine reuptake inhibitor (NRI). Analgesia in animal models is derived from both of these properties.
Approved Uses (Indications)
Lorazepam
INDICATIONS AND USAGE Lorazepam tablets are indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic. The effectiveness of lorazepam tablets in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The physician should periodically reassess the usefulness of the drug for the individual patient.
Tapentadol Hydrochloride
Tapentadol tablets are indicated for the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate in adults. Limitations of Use Because of the risks of addiction, abuse, misuse, overdose, and death, which can occur at any dose or duration [see Warnings and Precautions ], and persist over the course of therapy, reserve opioid analgesics, including tapentadol tablets for use in patients for whom alternative treatment options are ineffective, not tolerated, or would be otherwise inadequate to provide su…
Side Effects
Lorazepam
Tapentadol Hydrochloride
Cost Comparison
Lorazepam
$10–$50/month
Lorazepam is a widely available generic, making it relatively inexpensive. Patients can often find significant savings by using discount cards or comparing prices at different pharmacies.
Tapentadol Hydrochloride
$300–$800/month
Since Tapentadol Hydrochloride is only available as a brand-name drug, look for manufacturer coupons or patient assistance programs to significantly reduce costs. Discount cards like GoodRx can also offer some savings.
Compare prices for Lorazepam and Tapentadol Hydrochloride
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.