Combining Meloxicam and Ticagrelor is a major interaction and should generally be avoided without close medical supervision.
Combining meloxicam with ticagrelor significantly increases your risk of serious bleeding, including stomach bleeding. Your doctor may need to adjust your medications or monitor you closely.
Mechanism: Meloxicam, a non-steroidal anti-inflammatory drug (NSAID), inhibits prostaglandin synthesis, which can impair gastric mucosal protection and inhibit platelet aggregation. Ticagrelor is a potent antiplatelet agent that directly inhibits platelet aggregation. The combined antiplatelet effects and gastrointestinal mucosal damage synergistically increase bleeding risk.
Meloxicam vs. Ticagrelor
Compare Meloxicam and Ticagrelor: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Meloxicam
meloxicam
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Ticagrelor
Ticagrelor
Antiplatelet Agents
RxQuick Comparison
| Category | Meloxicam | Ticagrelor |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | Antiplatelet Agents |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $4–$20/month | $400–$700/month |
Meloxicam Overview
MELOXICAM (brand name: meloxicam) is a NSAIDs. 1 INDICATIONS AND USAGE Meloxicam Tablets are non-steroidal anti-inflammatory drug indicated for: Osteoarthritis (OA) ( 1.1 ) Rheumatoid Arthritis (RA) ( 1.2 ) Juvenile Rheumatoid Arthritis (JRA) in patients who weigh ≥ 60 kg ( 1.3 ) 1.1 Osteoarthritis (OA) Meloxicam tablets are indicated for…
Full Meloxicam guide →Ticagrelor Overview
Ticagrelor is an anti-platelet medication that helps prevent blood clots. It works by making your platelets (tiny blood cells involved in clotting) less sticky, reducing the risk of serious heart problems like heart attacks and strokes, especially in people with acute coronary syndrome or a history of heart disease.
Full Ticagrelor guide →How Each Drug Works
Meloxicam
Meloxicam has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of meloxicam, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Meloxicam is a potent inhibitor of prostaglandin synthesis in vitro . Meloxicam concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain i…
Ticagrelor
Ticagrelor and its major metabolite reversibly interact with the platelet P2Y 12 ADP-receptor to prevent signal transduction and platelet activation. Ticagrelor and its active metabolite are approximately equipotent.
Approved Uses (Indications)
Meloxicam
Meloxicam Tablets are non-steroidal anti-inflammatory drug indicated for: Osteoarthritis (OA) Rheumatoid Arthritis (RA) Juvenile Rheumatoid Arthritis (JRA) in patients who weigh ≥ 60 kg 1.1 Osteoarthritis (OA) Meloxicam tablets are indicated for relief of the signs and symptoms of osteoarthritis [see Clinical Studies ]. 1.2 Rheumatoid Arthritis (RA) Meloxicam tablets are indicated for relief of the signs and symptoms of rheumatoid arthritis [see Clinical Studies ].
Juvenile Rheumatoid Arthritis (JRA) Pauciarticular and Polya…
Ticagrelor
Ticagrelor tablets are a P2Y 12 platelet inhibitor indicated
- to reduce the risk of cardiovascular (CV) death, myocardial infarction (MI), and stroke in patients with acute coronary syndrome (ACS) or a history of MI. For at least the first 12 months following ACS, it is superior to clopidogrel. Ticagrelor tablets also reduce the risk of stent thrombosis in patients who have been stented for treatment of ACS.
- to reduce the risk of a first MI or stroke in patients with coronary artery disease (CAD) at high risk for such events. While use is not limited to this …
Side Effects
Meloxicam
Ticagrelor
Cost Comparison
Meloxicam
$4–$20/month
Meloxicam is available as an inexpensive generic. Patients can significantly reduce costs using discount cards or by checking prices at different pharmacies.
Ticagrelor
$400–$700/month
As a brand-name medication, Ticagrelor can be expensive. Patients should look for manufacturer patient assistance programs or discount cards like GoodRx to help reduce the cost.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.