Combining Metaxalone and Morphine is a major interaction and should generally be avoided without close medical supervision.
Patients may experience profound sedation, dizziness, confusion, and psychomotor impairment. The most serious clinical effect is an increased risk of respiratory depression, which can be life-threatening. Hypotension and syncope may also occur.
Mechanism: Morphine, an opioid agonist, primarily acts on mu-opioid receptors in the central nervous system (CNS) to produce analgesia and CNS depression. Metaxalone is a centrally acting muscle relaxant, whose exact mechanism is not fully understood but is thought to involve general CNS depression. The co-administration of these agents results in additive depressant effects on the CNS.
Metaxalone vs. Morphine
Compare Metaxalone and Morphine: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Metaxalone
Metaxalone
Skeletal Muscle Relaxants
RxDrug B
Morphine
Opium Tincture Deodorized
Opioid Analgesics
RxQuick Comparison
| Category | Metaxalone | Morphine |
|---|---|---|
| Drug Class | Skeletal Muscle Relaxants | Opioid Analgesics |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $200–$500/month | $200–$600/month |
Metaxalone Overview
Metaxalone is a muscle relaxant used to relieve discomfort from acute, painful muscle and bone conditions. While its exact action isn't fully understood, it's thought to help by causing a calming effect. It's typically used alongside rest and physical therapy to help patients feel better.
Full Metaxalone guide →Morphine Overview
MORPHINE (brand name: Opium Tincture Deodorized) is a Opioid Analgesics. INDICATIONS AND USAGE Opium tincture is useful for the treatment of diarrhea.
Full Morphine guide →How Each Drug Works
Metaxalone
Metaxalone’s mechanism of action has not been fully characterized, but may be related to its sedative properties. Metaxalone has no direct action on the contractile mechanism of striated muscle, the motor end plate, or the nerve fiber.
Approved Uses (Indications)
Metaxalone
Metaxalone tablets are indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions in adults and pediatric patients 13 years of age and older. Metaxalone is a muscle relaxant indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions in adults and pediatric patients 13 years of age and older.
Morphine
INDICATIONS AND USAGE Opium tincture is useful for the treatment of diarrhea.
Side Effects
Metaxalone
Morphine
Cost Comparison
Metaxalone
$200–$500/month
Since Metaxalone is only available as a brand-name drug, consider using manufacturer coupons or patient assistance programs to reduce costs. Discount cards like GoodRx may also offer some savings.
Morphine
$200–$600/month
As there is no generic available, patients should look for manufacturer patient assistance programs or discount cards to help reduce the cost of Opium Tincture Deodorized.
Compare prices for Metaxalone and Morphine
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.