Combining Metaxalone and Oxycodone is a major interaction and should generally be avoided without close medical supervision.
Patients may experience severe sedation, respiratory depression, dizziness, impaired psychomotor function, and confusion. In severe cases, this can lead to coma, respiratory arrest, and death. The impairment of motor skills can also increase the risk of falls and accidents.
Mechanism: Both oxycodone, an opioid analgesic, and metaxalone, a centrally acting muscle relaxant, exert central nervous system (CNS) depressant effects. This interaction is primarily pharmacodynamic, leading to an additive depressant effect on the brain and spinal cord. The combined action enhances GABAergic activity or reduces excitatory neurotransmission, resulting in profound CNS depression.
Metaxalone vs. Oxycodone
Compare Metaxalone and Oxycodone: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Metaxalone
Metaxalone
Skeletal Muscle Relaxants
RxDrug B
Oxycodone
Oxycodone Hydrochloride
Opioid Analgesics
RxQuick Comparison
| Category | Metaxalone | Oxycodone |
|---|---|---|
| Drug Class | Skeletal Muscle Relaxants | Opioid Analgesics |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $200–$500/month | $200–$600/month |
Metaxalone Overview
Metaxalone is a muscle relaxant used to relieve discomfort from acute, painful muscle and bone conditions. While its exact action isn't fully understood, it's thought to help by causing a calming effect. It's typically used alongside rest and physical therapy to help patients feel better.
Full Metaxalone guide →Oxycodone Overview
OXYCODONE (brand name: Oxycodone Hydrochloride) is a Opioid Analgesics. 1 INDICATIONS AND USAGE Oxycodone hydrochloride (HCl) tablets are indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Limitations of Use Because of the risks of addiction, abuse, and misuse with opioids, which can…
Full Oxycodone guide →How Each Drug Works
Metaxalone
Metaxalone’s mechanism of action has not been fully characterized, but may be related to its sedative properties. Metaxalone has no direct action on the contractile mechanism of striated muscle, the motor end plate, or the nerve fiber.
Oxycodone
Oxycodone is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid receptors at higher doses. The principal therapeutic action of oxycodone is analgesia. Like all full opioid agonists, there is no ceiling effect for analgesia with oxycodone. Clinically, dosage is titrated to provide adequate analgesia and may be limited by adverse reactions, including respiratory and CNS depression. The precise mechanism of the…
Approved Uses (Indications)
Metaxalone
Metaxalone tablets are indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions in adults and pediatric patients 13 years of age and older. Metaxalone is a muscle relaxant indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions in adults and pediatric patients 13 years of age and older.
Oxycodone
Oxycodone hydrochloride (HCl) tablets are indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Limitations of Use Because of the risks of addiction, abuse, and misuse with opioids, which can occur at any dosage or duration [see Warnings and Precautions ] , reserve oxycodone HCl tablets for use in patients for whom alternative treatment options (e.g., non-opioid analgesics or opioid combination products): Have not been tolerated or are not expected to be tolerated, Have not provided a…
Side Effects
Metaxalone
Oxycodone
Cost Comparison
Metaxalone
$200–$500/month
Since Metaxalone is only available as a brand-name drug, consider using manufacturer coupons or patient assistance programs to reduce costs. Discount cards like GoodRx may also offer some savings.
Oxycodone
$200–$600/month
As a brand-name medication, costs can be high without insurance. Manufacturer coupons or patient assistance programs may offer significant savings.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.