Combining Metaxalone and Tapentadol Hydrochloride is a major interaction and should generally be avoided without close medical supervision.
Patients may experience profound sedation, dizziness, confusion, and impaired psychomotor function. There is an increased risk of respiratory depression, which can be life-threatening, and hypotension. These effects significantly increase the risk of falls and accidental injury.
Mechanism: Tapentadol is an opioid analgesic with mu-opioid receptor agonist and norepinephrine reuptake inhibition properties, both contributing to central nervous system (CNS) depression. Metaxalone is a centrally acting skeletal muscle relaxant whose exact mechanism is not fully understood but is believed to involve general CNS depression. The coadministration of these agents leads to an additive depressant effect on the CNS.
Metaxalone vs. Tapentadol Hydrochloride
Compare Metaxalone and Tapentadol Hydrochloride: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Metaxalone
Metaxalone
Skeletal Muscle Relaxants
RxDrug B
Tapentadol Hydrochloride
Tapentadol Hydrochloride
Opioid Analgesics
RxQuick Comparison
| Category | Metaxalone | Tapentadol Hydrochloride |
|---|---|---|
| Drug Class | Skeletal Muscle Relaxants | Opioid Analgesics |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $200–$500/month | $300–$800/month |
Metaxalone Overview
Metaxalone is a muscle relaxant used to relieve discomfort from acute, painful muscle and bone conditions. While its exact action isn't fully understood, it's thought to help by causing a calming effect. It's typically used alongside rest and physical therapy to help patients feel better.
Full Metaxalone guide →Tapentadol Hydrochloride Overview
TAPENTADOL HYDROCHLORIDE (brand name: Tapentadol Hydrochloride) is a Opioid Analgesics. 1 INDICATIONS AND USAGE Tapentadol tablets are indicated for the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate in adults. Limitations of Use Because of the risks of addiction, abuse, misuse, overdose, and death, which can…
Full Tapentadol Hydrochloride guide →How Each Drug Works
Metaxalone
Metaxalone’s mechanism of action has not been fully characterized, but may be related to its sedative properties. Metaxalone has no direct action on the contractile mechanism of striated muscle, the motor end plate, or the nerve fiber.
Tapentadol Hydrochloride
Tapentadol is a centrally-acting synthetic analgesic. The exact mechanism of action is unknown. Although the clinical relevance is unclear, preclinical studies have shown that tapentadol is a mu-opioid receptor (MOR) agonist and a norepinephrine reuptake inhibitor (NRI). Analgesia in animal models is derived from both of these properties.
Approved Uses (Indications)
Metaxalone
Metaxalone tablets are indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions in adults and pediatric patients 13 years of age and older. Metaxalone is a muscle relaxant indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions in adults and pediatric patients 13 years of age and older.
Tapentadol Hydrochloride
Tapentadol tablets are indicated for the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate in adults. Limitations of Use Because of the risks of addiction, abuse, misuse, overdose, and death, which can occur at any dose or duration [see Warnings and Precautions ], and persist over the course of therapy, reserve opioid analgesics, including tapentadol tablets for use in patients for whom alternative treatment options are ineffective, not tolerated, or would be otherwise inadequate to provide su…
Side Effects
Metaxalone
Tapentadol Hydrochloride
Cost Comparison
Metaxalone
$200–$500/month
Since Metaxalone is only available as a brand-name drug, consider using manufacturer coupons or patient assistance programs to reduce costs. Discount cards like GoodRx may also offer some savings.
Tapentadol Hydrochloride
$300–$800/month
Since Tapentadol Hydrochloride is only available as a brand-name drug, look for manufacturer coupons or patient assistance programs to significantly reduce costs. Discount cards like GoodRx can also offer some savings.
Compare prices for Metaxalone and Tapentadol Hydrochloride
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.