Combining Metaxalone and Tramadol Hydrochloride is a major interaction and should generally be avoided without close medical supervision.
Patients may experience profound sedation, respiratory depression, hypotension, dizziness, and impaired psychomotor function. This combination significantly increases the risk of falls, accidental injury, and potentially life-threatening respiratory compromise.
Mechanism: Both tramadol and metaxalone exert central nervous system (CNS) depressant effects. Tramadol acts as a weak opioid agonist and also inhibits the reuptake of norepinephrine and serotonin, while metaxalone's muscle relaxant properties are attributed to general CNS depression. The co-administration leads to an additive depressant effect on the CNS.
Metaxalone vs. Tramadol Hydrochloride
Compare Metaxalone and Tramadol Hydrochloride: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Metaxalone
Metaxalone
Skeletal Muscle Relaxants
RxDrug B
Tramadol Hydrochloride
Tramadol Hydrochloride
Opioid Analgesics
RxQuick Comparison
| Category | Metaxalone | Tramadol Hydrochloride |
|---|---|---|
| Drug Class | Skeletal Muscle Relaxants | Opioid Analgesics |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $200–$500/month | $15–$50/month |
Metaxalone Overview
Metaxalone is a muscle relaxant used to relieve discomfort from acute, painful muscle and bone conditions. While its exact action isn't fully understood, it's thought to help by causing a calming effect. It's typically used alongside rest and physical therapy to help patients feel better.
Full Metaxalone guide →Tramadol Hydrochloride Overview
TRAMADOL HYDROCHLORIDE (brand name: TRAMADOL HYDROCHLORIDE) is a Opioid Analgesics. 1 INDICATIONS AND USAGE Tramadol hydrochloride tablets are indicated in adults for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Limitations of Use Because of the risks of addiction, abuse, and misuse with opioids, which can…
Full Tramadol Hydrochloride guide →How Each Drug Works
Metaxalone
Metaxalone’s mechanism of action has not been fully characterized, but may be related to its sedative properties. Metaxalone has no direct action on the contractile mechanism of striated muscle, the motor end plate, or the nerve fiber.
Tramadol Hydrochloride
Tramadol hydrochloride contains tramadol, an opioid agonist and inhibitor of norepinephrine and serotonin re-uptake. Although the mode of action is not completely understood, the analgesic effect of tramadol is believed to be due to both binding to μ-opioid receptors and weak inhibition of re-uptake of norepinephrine and serotonin. Opioid activity is due to both low affinity binding of the parent compound and higher affinity binding of the O -demethylated metabolite M1 t…
Approved Uses (Indications)
Metaxalone
Metaxalone tablets are indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions in adults and pediatric patients 13 years of age and older. Metaxalone is a muscle relaxant indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions in adults and pediatric patients 13 years of age and older.
Tramadol Hydrochloride
Tramadol hydrochloride tablets are indicated in adults for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Limitations of Use Because of the risks of addiction, abuse, and misuse with opioids, which can occur at any dosage or duration [see Warnings and Precautions ] , reserve tramadol hydrochloride tablets for use in patients for whom alternative treatment options (e.g., non-opioid analgesics or opioid combination products): Have not been tolerated or are not expected to be tolerated. Have no…
Side Effects
Metaxalone
Tramadol Hydrochloride
Cost Comparison
Metaxalone
$200–$500/month
Since Metaxalone is only available as a brand-name drug, consider using manufacturer coupons or patient assistance programs to reduce costs. Discount cards like GoodRx may also offer some savings.
Tramadol Hydrochloride
$15–$50/month
Tramadol Hydrochloride is available as a generic, making it generally affordable. Using discount cards like GoodRx can further reduce the cost, often bringing it down to under $20 per month.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.