Methadone and Temazepam must not be used together. This combination is classified as CONTRAINDICATED.
The combination significantly increases the risk of severe respiratory depression, profound sedation, coma, and death. Patients may experience decreased level of consciousness, hypoventilation, pinpoint pupils, and hypotension.
Mechanism: Both methadone, an opioid agonist, and temazepam, a benzodiazepine, are central nervous system (CNS) depressants. Their co-administration leads to additive CNS depression by enhancing GABAergic neurotransmission (benzodiazepines) and activating mu-opioid receptors (methadone), resulting in synergistic effects on respiratory drive and sedation.
Methadone vs. Temazepam
Compare Methadone and Temazepam: mechanism of action, indications, side effects, cost, and which may be right for you.
Quick Comparison
| Category | Methadone | Temazepam |
|---|---|---|
| Drug Class | Opioid Analgesics | Benzodiazepines |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $15–$60/month | $20–$70/month |
Methadone Overview
METHADONE (brand name: Methadone Hydrochloride) is a Opioid Analgesics. 1 INDICATIONS AND USAGE Methadone hydrochloride tablets is indicated for the: Management of severe and persistent pain that requires an opioid analgesic and that cannot be adequately treated with alternative options, including immediate-release opioids. Limitations of Use Because of the risks of…
Full Methadone guide →Temazepam Overview
TEMAZEPAM (brand name: temazepam) is a Benzodiazepines. INDICATIONS & USAGE Temazepam Capsules, USP are indicated for the short-term treatment of insomnia (generally 7 to 10 days). For patients with short-term insomnia, instructions in the prescription should indicate that Temazepam Capsules should be used for short periods of time (7 to 10 days). The…
Full Temazepam guide →How Each Drug Works
Methadone
Methadone hydrochloride is a mu-agonist; a synthetic opioid with multiple actions qualitatively similar to those of morphine, the most prominent of which involves the central nervous system and organs composed of smooth muscle. The principal therapeutic uses for methadone are for analgesia and for detoxification or maintenance in opioid addiction. The methadone withdrawal syndrome, although qualitatively similar to that of morphine, differs in that the onset is slower, t…
Approved Uses (Indications)
Methadone
Methadone hydrochloride tablets is indicated for the: Management of severe and persistent pain that requires an opioid analgesic and that cannot be adequately treated with alternative options, including immediate-release opioids. Limitations of Use Because of the risks of addiction, abuse, misuse, overdose, and death, which can occur at any dosage or duration and persist over the course of therapy [see WARNINGS AND PRECAUTIONS ], reserve opioid analgesics, including methadone hydrochloride tablets, for use in patients for whom alternative analgesic treatment opti…
Temazepam
INDICATIONS & USAGE Temazepam Capsules, USP are indicated for the short-term treatment of insomnia (generally 7 to 10 days). For patients with short-term insomnia, instructions in the prescription should indicate that Temazepam Capsules should be used for short periods of time (7 to 10 days). The clinical trials performed in support of efficacy were 2 weeks in duration with the final formal assessment of sleep latency performed at the end of treatment.
Side Effects
Methadone
Temazepam
Cost Comparison
Methadone
$15–$60/month
Generic methadone is very affordable, especially with discount cards like GoodRx. Many pharmacies offer low-cost programs for this medication.
Temazepam
$20–$70/month
Although there is no generic available, discount cards like GoodRx can often help reduce the cost of Temazepam significantly. Comparing prices at different pharmacies is also recommended.
Compare prices for Methadone and Temazepam
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Medical Disclaimer
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