Combining Metoprolol Succinate and Paroxetine is a major interaction and should generally be avoided without close medical supervision.
The co-administration of paroxetine with metoprolol can significantly increase metoprolol plasma concentrations, leading to enhanced beta-blockade effects. This interaction can result in severe bradycardia, hypotension, and heart block, posing a significant risk to the patient.
Mechanism: Paroxetine is a potent inhibitor of cytochrome P450 2D6 (CYP2D6), the primary enzyme responsible for the metabolism of metoprolol. Inhibition of CYP2D6 by paroxetine reduces metoprolol clearance, thereby increasing its systemic exposure and pharmacodynamic effects.
Metoprolol Succinate vs. Paroxetine
Compare Metoprolol Succinate and Paroxetine: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Metoprolol Succinate
Metoprolol Succinate
Beta-Blockers
RxDrug B
Paroxetine
Paroxetine
SSRIs (Selective Serotonin Reuptake Inhibitors)
RxQuick Comparison
| Category | Metoprolol Succinate | Paroxetine |
|---|---|---|
| Drug Class | Beta-Blockers | SSRIs (Selective Serotonin Reuptake Inhibitors) |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $4-$25/month | $15–$70/month |
Metoprolol Succinate Overview
METOPROLOL SUCCINATE (brand name: Metoprolol Succinate) is a Beta-Blockers. 1 INDICATIONS & USAGE Metoprolol succinate extended-release tablets, metoprolol succinate, beta-adrenergic blocker indicated for the treatment of: • Hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and…
Full Metoprolol Succinate guide →Paroxetine Overview
Paroxetine is a prescription medication used to help women manage moderate to severe hot flashes and night sweats (vasomotor symptoms) associated with menopause. While it belongs to a class of drugs that can affect brain chemicals, this specific formulation works differently and is not used to treat mental health conditions.
Full Paroxetine guide →How Each Drug Works
Paroxetine
Nonclinical studies have shown that paroxetine is an SSRI. Paroxetine capsules are not an estrogen, and its mechanism of action for the treatment of VMS is unknown.
Approved Uses (Indications)
Metoprolol Succinate
Metoprolol succinate extended-release tablets, metoprolol succinate, beta-adrenergic blocker indicated for the treatment of:
- Hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.()
- Angina Pectoris. ()
- Heart Failure, to reduce the risk of cardiovascular mortality and heart failure hospitalizations in patients with heart failure() 1.1 Hypertension Metoprolol succinate extended-release tablets is indicated for the treatment of hypertension, to lower blo…
Paroxetine
Paroxetine Capsules are indicated for the treatment of moderate to severe vasomotor symptoms (VMS) associated with menopause. Limitation of Use: Paroxetine capsules are not indicated for the treatment of any psychiatric condition. Paroxetine capsules contain a lower dose of paroxetine than that used to treat depression, obsessive compulsive disorder, panic disorder, generalized anxiety disorder, social anxiety disorder, and post-traumatic stress disorder. The safety and efficacy of this lower dose of paroxetine in paroxetine capsules have not been established for any ps…
Side Effects
Metoprolol Succinate
Paroxetine
Cost Comparison
Metoprolol Succinate
$4-$25/month
Metoprolol Succinate is available as a low-cost generic. Patients can often find significant savings by using discount cards or patient assistance programs.
Paroxetine
$15–$70/month
Paroxetine is available as a generic, which is significantly more affordable than the brand-name versions. Always compare prices using discount cards like GoodRx to find the lowest cost at different pharmacies.
Compare prices for Metoprolol Succinate and Paroxetine
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.