Drug Comparison

Metoprolol Tartrate vs. Sertraline

Compare Metoprolol Tartrate and Sertraline: mechanism of action, indications, side effects, cost, and which may be right for you.

Quick Comparison

CategoryMetoprolol TartrateSertraline
Drug ClassBeta-BlockersSSRIs (Selective Serotonin Reuptake Inhibitors)
Rx StatusRxRx
Generic AvailableNoYes
Typical Cost$4–$25/month$4–$25/month

Metoprolol Tartrate Overview

Metoprolol Tartrate is a beta-blocker medication used to treat high blood pressure, chest pain (angina), and to improve outcomes after a heart attack. It works by relaxing blood vessels and slowing the heart rate, which helps to lower blood pressure and reduce the heart's workload.

Full Metoprolol Tartrate guide →

Sertraline Overview

Sertraline (brand name: Sertraline) is a medication known as a selective serotonin reuptake inhibitor (SSRI). It is used to treat various mental health conditions, including depression, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder. Sertraline works by helping to restore the balance of a natural substance...

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How Each Drug Works

Sertraline

Sertraline potentiates serotonergic activity in the central nervous system through inhibition of neuronal reuptake of serotonin (5-HT).

Approved Uses (Indications)

Metoprolol Tartrate

Metoprolol tartrate is a beta-adrenergic blocker indicated for the treatment of:

  • Hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.
  • Angina Pectoris.
  • Myocardial Infarction, to reduce the risk of cardiovascular mortality when used in conjunction with intravenous metoprolol therapy in patients with definite or suspected acute myocardial infarction in hemodynamically stable patients.

Hypertension Metoprolol tartrate is in…

Sertraline

Sertraline hydrochloride tablets are indicated for the treatment of the following [See Clinical Studies ] : Major depressive disorder (MDD) Obsessive-compulsive disorder (OCD) Panic disorder (PD) Posttraumatic stress disorder (PTSD) Social anxiety disorder (SAD) Premenstrual dysphoric disorder (PMDD) Sertraline hydrochloride tablet is a selective serotonin reuptake inhibitor (SSRI) indicated for the treatment of : Major depressive disorder (MDD) Obsessive-compulsive disorder (OCD) Panic disorder (PD) Post-traumatic stress disorder (PTSD) Social anxiety disord…

Side Effects

Metoprolol Tartrate

Sertraline

Cost Comparison

Metoprolol Tartrate

$4–$25/month

As a widely available generic, Metoprolol Tartrate is typically affordable. Using discount cards like GoodRx can further reduce the cost, often bringing it down to under $10 per month at many pharmacies.

Sertraline

$4–$25/month

Generic available

As a widely available generic, Sertraline is very affordable. Patients can often find it for under $10 per month using discount cards or pharmacy programs.

Drug Interaction: Moderate

SSRIs can increase metoprolol plasma levels by inhibiting CYP2D6, potentially causing excessive beta-blockade.

Mechanism: Sertraline moderately inhibits CYP2D6, which is the primary metabolic pathway for metoprolol, increasing metoprolol AUC by 30–100%.

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Medical Disclaimer

The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.