Metoprolol Tartrate and Verapamil Hydrochloride must not be used together. This combination is classified as CONTRAINDICATED.
Combining a beta-blocker with verapamil can cause severe bradycardia, heart block, and cardiac arrest.
Mechanism: Both drugs independently slow AV node conduction. Combined use produces additive negative chronotropic and dromotropic effects.
Metoprolol Tartrate vs. Verapamil Hydrochloride
Compare Metoprolol Tartrate and Verapamil Hydrochloride: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Metoprolol Tartrate
Metoprolol Tartrate
Beta-Blockers
RxDrug B
Verapamil Hydrochloride
Verapamil Hydrochloride
Calcium Channel Blockers
RxQuick Comparison
| Category | Metoprolol Tartrate | Verapamil Hydrochloride |
|---|---|---|
| Drug Class | Beta-Blockers | Calcium Channel Blockers |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $4–$25/month | $200–$500/month |
Metoprolol Tartrate Overview
Metoprolol Tartrate is a beta-blocker medication used to treat high blood pressure, chest pain (angina), and to improve outcomes after a heart attack. It works by relaxing blood vessels and slowing the heart rate, which helps to lower blood pressure and reduce the heart's workload.
Full Metoprolol Tartrate guide →Verapamil Hydrochloride Overview
Verapamil Hydrochloride is a medication known as a calcium channel blocker, used to treat conditions like high blood pressure, certain types of irregular heartbeats, and chest pain (angina). It works by relaxing blood vessels and slowing down the heart rate, which helps to improve blood flow and reduce the heart's workload.
Full Verapamil Hydrochloride guide →How Each Drug Works
Verapamil Hydrochloride
Mechanism of Action Angina: The precise mechanism of action of verapamil hydrochloride as an antianginal agent remains to be fully determined, but includes the following two mechanisms: Relaxation and prevention of coronary artery spasm: Verapamil hydrochloride dilates the main coronary arteries and coronary arterioles, both in normal and ischemic regions, and is a potent inhibitor of coronary artery spasm, whether spontaneous or ergonovine-induced. This property increases myocardial oxygen deli…
Approved Uses (Indications)
Metoprolol Tartrate
Metoprolol tartrate is a beta-adrenergic blocker indicated for the treatment of:
- Hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.
- Angina Pectoris.
- Myocardial Infarction, to reduce the risk of cardiovascular mortality when used in conjunction with intravenous metoprolol therapy in patients with definite or suspected acute myocardial infarction in hemodynamically stable patients.
Hypertension Metoprolol tartrate is in…
Verapamil Hydrochloride
INDICATIONS AND USAGE Verapamil hydrochloride tablets, USP are indicated for the treatment of the following: Angina 1. Angina at rest including: - Vasospastic (Prinzmetal's variant) angina - Unstable (crescendo, pre-infarction) angina 2. Chronic stable angina (classic effort-associated angina) Arrhythmias In association with digitalis for the control of ventricular rate at rest and during stress in patients with chronic atrial flutter and/or atrial fibrillation (see WARNINGS : Accessory bypass tract) Prophylaxis of repetitive paroxysmal supraventricular tachycardia Essential hypertension Verap…
Side Effects
Metoprolol Tartrate
Verapamil Hydrochloride
Cost Comparison
Metoprolol Tartrate
$4–$25/month
As a widely available generic, Metoprolol Tartrate is typically affordable. Using discount cards like GoodRx can further reduce the cost, often bringing it down to under $10 per month at many pharmacies.
Verapamil Hydrochloride
$200–$500/month
As a brand-only medication, Verapamil Hydrochloride can be expensive. Look for manufacturer coupons or patient assistance programs to help reduce the cost, and always compare prices at different pharmacies.
Compare prices for Metoprolol Tartrate and Verapamil Hydrochloride
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Medical Disclaimer
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