Midazolam and Tramadol Hydrochloride must not be used together. This combination is classified as CONTRAINDICATED.
Concomitant use can cause severe respiratory depression, profound sedation, hypotension, psychomotor impairment, coma, and death. Patients may exhibit decreased level of consciousness, bradycardia, hypoventilation, and cyanosis.
Mechanism: Both tramadol (an opioid analgesic) and midazolam (a benzodiazepine) are central nervous system (CNS) depressants. Their coadministration leads to additive pharmacodynamic effects, significantly enhancing GABAergic inhibition and mu-opioid receptor agonism, resulting in profound CNS and respiratory depression.
Midazolam vs. Tramadol Hydrochloride
Compare Midazolam and Tramadol Hydrochloride: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Midazolam
Midazolam
Benzodiazepines
RxDrug B
Tramadol Hydrochloride
Tramadol Hydrochloride
Opioid Analgesics
RxQuick Comparison
| Category | Midazolam | Tramadol Hydrochloride |
|---|---|---|
| Drug Class | Benzodiazepines | Opioid Analgesics |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $500–$1,500/month | $15–$50/month |
Midazolam Overview
Midazolam is a type of medicine called a benzodiazepine that helps calm the body and mind. It is primarily used to make you feel relaxed and drowsy before medical procedures, surgeries, or to help you fall asleep for general anesthesia. It works by slowing down brain activity to reduce anxiety and create a state of peacefulness or forgetfulness.
Full Midazolam guide →Tramadol Hydrochloride Overview
TRAMADOL HYDROCHLORIDE (brand name: TRAMADOL HYDROCHLORIDE) is a Opioid Analgesics. 1 INDICATIONS AND USAGE Tramadol hydrochloride tablets are indicated in adults for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Limitations of Use Because of the risks of addiction, abuse, and misuse with opioids, which can…
Full Tramadol Hydrochloride guide →How Each Drug Works
Tramadol Hydrochloride
Tramadol hydrochloride contains tramadol, an opioid agonist and inhibitor of norepinephrine and serotonin re-uptake. Although the mode of action is not completely understood, the analgesic effect of tramadol is believed to be due to both binding to μ-opioid receptors and weak inhibition of re-uptake of norepinephrine and serotonin. Opioid activity is due to both low affinity binding of the parent compound and higher affinity binding of the O -demethylated metabolite M1 t…
Approved Uses (Indications)
Midazolam
INDICATIONS AND USAGE Midazolam Injection is indicated: intramuscularly or intravenously for preoperative sedation/anxiolysis/amnesia; intravenously as an agent for sedation/anxiolysis/amnesia prior to or during diagnostic, therapeutic or endoscopic procedures, such as bronchoscopy, gastroscopy, cystoscopy, coronary angiography, cardiac catheterization, oncology procedures, radiologic procedures, suture of lacerations and other procedures either alone or in combination with other CNS depressants; intravenously for induction of general anesthesia, before administration of other anesthetic agent…
Tramadol Hydrochloride
Tramadol hydrochloride tablets are indicated in adults for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Limitations of Use Because of the risks of addiction, abuse, and misuse with opioids, which can occur at any dosage or duration [see Warnings and Precautions ] , reserve tramadol hydrochloride tablets for use in patients for whom alternative treatment options (e.g., non-opioid analgesics or opioid combination products): Have not been tolerated or are not expected to be tolerated. Have no…
Side Effects
Midazolam
Tramadol Hydrochloride
Cost Comparison
Midazolam
$500–$1,500/month
As Midazolam is a brand-only medication, explore manufacturer patient assistance programs or discount cards like GoodRx to help reduce the high cost. Your insurance plan's coverage will also significantly impact your out-of-pocket expenses.
Tramadol Hydrochloride
$15–$50/month
Tramadol Hydrochloride is available as a generic, making it generally affordable. Using discount cards like GoodRx can further reduce the cost, often bringing it down to under $20 per month.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.