Morphine and Temazepam must not be used together. This combination is classified as CONTRAINDICATED.
The concurrent use of morphine and temazepam significantly increases the risk of severe adverse effects including profound sedation, respiratory depression, coma, and death. Patients may experience decreased level of consciousness, hypoventilation, hypotension, and psychomotor impairment. This combination can lead to life-threatening respiratory insufficiency.
Mechanism: Morphine, an opioid agonist, binds to mu-opioid receptors in the central nervous system (CNS), leading to CNS depression, analgesia, and respiratory depression. Temazepam, a benzodiazepine, enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) at GABA-A receptors, also resulting in CNS depression, sedation, and anxiolysis. The synergistic CNS depressant effects of both drugs lead to profound respiratory depression.
Morphine vs. Temazepam
Compare Morphine and Temazepam: mechanism of action, indications, side effects, cost, and which may be right for you.
Quick Comparison
| Category | Morphine | Temazepam |
|---|---|---|
| Drug Class | Opioid Analgesics | Benzodiazepines |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $200–$600/month | $20–$70/month |
Morphine Overview
MORPHINE (brand name: Opium Tincture Deodorized) is a Opioid Analgesics. INDICATIONS AND USAGE Opium tincture is useful for the treatment of diarrhea.
Full Morphine guide →Temazepam Overview
TEMAZEPAM (brand name: temazepam) is a Benzodiazepines. INDICATIONS & USAGE Temazepam Capsules, USP are indicated for the short-term treatment of insomnia (generally 7 to 10 days). For patients with short-term insomnia, instructions in the prescription should indicate that Temazepam Capsules should be used for short periods of time (7 to 10 days). The…
Full Temazepam guide →Approved Uses (Indications)
Morphine
INDICATIONS AND USAGE Opium tincture is useful for the treatment of diarrhea.
Temazepam
INDICATIONS & USAGE Temazepam Capsules, USP are indicated for the short-term treatment of insomnia (generally 7 to 10 days). For patients with short-term insomnia, instructions in the prescription should indicate that Temazepam Capsules should be used for short periods of time (7 to 10 days). The clinical trials performed in support of efficacy were 2 weeks in duration with the final formal assessment of sleep latency performed at the end of treatment.
Side Effects
Morphine
Temazepam
Cost Comparison
Morphine
$200–$600/month
As there is no generic available, patients should look for manufacturer patient assistance programs or discount cards to help reduce the cost of Opium Tincture Deodorized.
Temazepam
$20–$70/month
Although there is no generic available, discount cards like GoodRx can often help reduce the cost of Temazepam significantly. Comparing prices at different pharmacies is also recommended.
Compare prices for Morphine and Temazepam
Check real-time pharmacy prices before you fill — free, no account needed.
Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.