Combining Naproxen and Ticagrelor is a major interaction and should generally be avoided without close medical supervision.
Combining naproxen with ticagrelor significantly increases your risk of bleeding, especially in the stomach or intestines. This combination should generally be avoided due to the serious potential for harm.
Mechanism: Naproxen, an NSAID, inhibits cyclooxygenase (COX-1 and COX-2), reducing prostaglandin synthesis, which impairs gastric mucosal protection and platelet aggregation. Ticagrelor is a P2Y12 inhibitor that prevents platelet activation and aggregation through a different mechanism. The concurrent use of both agents leads to an additive antiplatelet effect and increased gastrointestinal mucosal damage, profoundly elevating bleeding risk.
Naproxen vs. Ticagrelor
Compare Naproxen and Ticagrelor: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Naproxen
Naproxen
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Ticagrelor
Ticagrelor
Antiplatelet Agents
RxQuick Comparison
| Category | Naproxen | Ticagrelor |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | Antiplatelet Agents |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $4–$25/month | $400–$700/month |
Naproxen Overview
NAPROXEN (brand name: Naproxen) is a NSAIDs. 1 INDICATIONS & USAGE Naproxen delayed-release tablets are indicated for: the relief of the signs and symptoms of: rheumatoid arthritis osteoarthritis ankylosing spondylitis Polyarticular Juvenile Idiopathic Arthritis Naproxen delayed-release tablets are non-steroidal anti-inflammatory drugs…
Full Naproxen guide →Ticagrelor Overview
Ticagrelor is an anti-platelet medication that helps prevent blood clots. It works by making your platelets (tiny blood cells involved in clotting) less sticky, reducing the risk of serious heart problems like heart attacks and strokes, especially in people with acute coronary syndrome or a history of heart disease.
Full Ticagrelor guide →How Each Drug Works
Naproxen
Naproxen has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of naproxen, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Naproxen is a potent inhibitor of prostaglandin synthesis in vitro. Naproxen concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in ani…
Ticagrelor
Ticagrelor and its major metabolite reversibly interact with the platelet P2Y 12 ADP-receptor to prevent signal transduction and platelet activation. Ticagrelor and its active metabolite are approximately equipotent.
Approved Uses (Indications)
Naproxen
Naproxen delayed-release tablets are indicated for: the relief of the signs and symptoms of: rheumatoid arthritis osteoarthritis ankylosing spondylitis Polyarticular Juvenile Idiopathic Arthritis Naproxen delayed-release tablets are non-steroidal anti-inflammatory drugs indicated for: the relief of the signs and symptoms of: rheumatoid arthritis osteoarthritis ankylosing spondylitis polyarticular juvenile idiopathic arthritis
Ticagrelor
Ticagrelor tablets are a P2Y 12 platelet inhibitor indicated
- to reduce the risk of cardiovascular (CV) death, myocardial infarction (MI), and stroke in patients with acute coronary syndrome (ACS) or a history of MI. For at least the first 12 months following ACS, it is superior to clopidogrel. Ticagrelor tablets also reduce the risk of stent thrombosis in patients who have been stented for treatment of ACS.
- to reduce the risk of a first MI or stroke in patients with coronary artery disease (CAD) at high risk for such events. While use is not limited to this …
Side Effects
Naproxen
Ticagrelor
Cost Comparison
Naproxen
$4–$25/month
Naproxen is widely available as an affordable generic. Using discount cards like GoodRx can further reduce the cost, often bringing it to under $10 per month.
Ticagrelor
$400–$700/month
As a brand-name medication, Ticagrelor can be expensive. Patients should look for manufacturer patient assistance programs or discount cards like GoodRx to help reduce the cost.
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Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.