Combining Naproxen and Warfarin Sodium is a major interaction and should generally be avoided without close medical supervision.
Concomitant use of warfarin and naproxen significantly increases the risk of bleeding, including serious gastrointestinal bleeding. Patients may experience bruising, epistaxis, hematuria, or more severe hemorrhagic events.
Mechanism: Naproxen, an NSAID, inhibits platelet aggregation and can cause gastrointestinal irritation and ulceration. Warfarin is an anticoagulant that inhibits vitamin K-dependent clotting factors. The combined antiplatelet and anticoagulant effects, along with GI mucosal damage from naproxen, lead to an additive increase in bleeding risk.
Naproxen vs. Warfarin Sodium
Compare Naproxen and Warfarin Sodium: mechanism of action, indications, side effects, cost, and which may be right for you.
Drug A
Naproxen
Naproxen
NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
RxDrug B
Warfarin Sodium
Warfarin Sodium
Anticoagulants
RxQuick Comparison
| Category | Naproxen | Warfarin Sodium |
|---|---|---|
| Drug Class | NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) | Anticoagulants |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $4–$25/month | $10–$50/month |
Naproxen Overview
NAPROXEN (brand name: Naproxen) is a NSAIDs. 1 INDICATIONS & USAGE Naproxen delayed-release tablets are indicated for: the relief of the signs and symptoms of: rheumatoid arthritis osteoarthritis ankylosing spondylitis Polyarticular Juvenile Idiopathic Arthritis Naproxen delayed-release tablets are non-steroidal anti-inflammatory drugs…
Full Naproxen guide →Warfarin Sodium Overview
Warfarin Sodium is a "blood thinner" (anticoagulant) medication that helps prevent and treat harmful blood clots in the body. It works by reducing the body's ability to form clots, which can help prevent serious conditions like strokes, heart attacks, and clots in the legs or lungs, especially in people with certain heart conditions or after a heart attack.
Full Warfarin Sodium guide →How Each Drug Works
Naproxen
Naproxen has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of naproxen, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Naproxen is a potent inhibitor of prostaglandin synthesis in vitro. Naproxen concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in ani…
Warfarin Sodium
Warfarin acts by inhibiting the synthesis of vitamin K-dependent clotting factors, which include Factors II, VII, IX, and X, and the anticoagulant proteins C and S. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K-dependent clotting factors. Vitamin K promotes the biosynthesis of γ-carboxyglutamic acid residues in the proteins that are essential for biological activity. Warfarin is thought to interfere with clotting factor synthesis by…
Approved Uses (Indications)
Naproxen
Naproxen delayed-release tablets are indicated for: the relief of the signs and symptoms of: rheumatoid arthritis osteoarthritis ankylosing spondylitis Polyarticular Juvenile Idiopathic Arthritis Naproxen delayed-release tablets are non-steroidal anti-inflammatory drugs indicated for: the relief of the signs and symptoms of: rheumatoid arthritis osteoarthritis ankylosing spondylitis polyarticular juvenile idiopathic arthritis
Warfarin Sodium
Warfarin sodium tablets are indicated for: Prophylaxis and treatment of venous thrombosis and its extension, pulmonary embolism (PE). Prophylaxis and treatment of thromboembolic complications associated with atrial fibrillation (AF) and/or cardiac valve replacement. Reduction in the risk of death, recurrent myocardial infarction (MI), and thromboembolic events such as stroke or systemic embolization after myocardial infarction. Limitations of Use Warfarin sodium tablets have no direct effect on an established thrombus, nor does it reverse ischemic tissue damage. Once a …
Side Effects
Naproxen
Warfarin Sodium
Cost Comparison
Naproxen
$4–$25/month
Naproxen is widely available as an affordable generic. Using discount cards like GoodRx can further reduce the cost, often bringing it to under $10 per month.
Warfarin Sodium
$10–$50/month
Warfarin Sodium is available as an affordable generic. Using discount cards like GoodRx can further reduce the cost, often bringing it down to under $10 per month at many pharmacies.
Compare prices for Naproxen and Warfarin Sodium
Check real-time pharmacy prices before you fill — free, no account needed.
Medical Disclaimer
The information on RxGuide is intended for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician, pharmacist, or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.