Combining Oxycodone and Temazepam is a major interaction and should generally be avoided without close medical supervision.
Patients may experience severe respiratory depression, characterized by decreased respiratory rate and depth, hypoxemia, and hypercapnia. Profound sedation, somnolence, dizziness, impaired psychomotor function, and hypotension are also common. In severe cases, this can progress to coma and death.
Mechanism: Both oxycodone (an opioid analgesic) and temazepam (a benzodiazepine) are central nervous system (CNS) depressants. Their co-administration leads to an additive depressant effect on the CNS, particularly affecting the brainstem respiratory centers and consciousness. This synergistic depression significantly increases the risk of respiratory depression, profound sedation, and coma.
Oxycodone vs. Temazepam
Compare Oxycodone and Temazepam: mechanism of action, indications, side effects, cost, and which may be right for you.
Quick Comparison
| Category | Oxycodone | Temazepam |
|---|---|---|
| Drug Class | Opioid Analgesics | Benzodiazepines |
| Rx Status | Rx | Rx |
| Generic Available | No | No |
| Typical Cost | $200–$600/month | $20–$70/month |
Oxycodone Overview
OXYCODONE (brand name: Oxycodone Hydrochloride) is a Opioid Analgesics. 1 INDICATIONS AND USAGE Oxycodone hydrochloride (HCl) tablets are indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Limitations of Use Because of the risks of addiction, abuse, and misuse with opioids, which can…
Full Oxycodone guide →Temazepam Overview
TEMAZEPAM (brand name: temazepam) is a Benzodiazepines. INDICATIONS & USAGE Temazepam Capsules, USP are indicated for the short-term treatment of insomnia (generally 7 to 10 days). For patients with short-term insomnia, instructions in the prescription should indicate that Temazepam Capsules should be used for short periods of time (7 to 10 days). The…
Full Temazepam guide →How Each Drug Works
Oxycodone
Oxycodone is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid receptors at higher doses. The principal therapeutic action of oxycodone is analgesia. Like all full opioid agonists, there is no ceiling effect for analgesia with oxycodone. Clinically, dosage is titrated to provide adequate analgesia and may be limited by adverse reactions, including respiratory and CNS depression. The precise mechanism of the…
Approved Uses (Indications)
Oxycodone
Oxycodone hydrochloride (HCl) tablets are indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Limitations of Use Because of the risks of addiction, abuse, and misuse with opioids, which can occur at any dosage or duration [see Warnings and Precautions ] , reserve oxycodone HCl tablets for use in patients for whom alternative treatment options (e.g., non-opioid analgesics or opioid combination products): Have not been tolerated or are not expected to be tolerated, Have not provided a…
Temazepam
INDICATIONS & USAGE Temazepam Capsules, USP are indicated for the short-term treatment of insomnia (generally 7 to 10 days). For patients with short-term insomnia, instructions in the prescription should indicate that Temazepam Capsules should be used for short periods of time (7 to 10 days). The clinical trials performed in support of efficacy were 2 weeks in duration with the final formal assessment of sleep latency performed at the end of treatment.
Side Effects
Oxycodone
Temazepam
Cost Comparison
Oxycodone
$200–$600/month
As a brand-name medication, costs can be high without insurance. Manufacturer coupons or patient assistance programs may offer significant savings.
Temazepam
$20–$70/month
Although there is no generic available, discount cards like GoodRx can often help reduce the cost of Temazepam significantly. Comparing prices at different pharmacies is also recommended.
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Medical Disclaimer
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